Mia Malkova and her boyfriend try to do things out of the blue and enter a desert even after there is a no-entry board written on it. In this situation, scary things and some crazy people start troubling them. The couple runs for their life and reaches a small town only to know there are more dangerous situations are in store for them. Who is behind these incidents and how the couple comes out of this mess forms the crux of the story.

In 1995, Russian undercover agents, super-soldier Alexei Shostakov and Black Widow Melina Vostokoff pose as a normal family in Ohio, along with their surrogate daughters Natasha Romanoff and Yelena Belova. When the mission to steal S.H.I.E.L.D. intel is complete, the family escapes to Cuba to rendezvous with their boss Dreykov, who has Romanoff and Belova put through the Red Room for training, while Shostakov is imprisoned in Russia. Years pass and Romanoff defects to S.H.I.E.L.D. after bombing Dreykov's office, apparently killing him and his young daughter Antonia. In 2016, Romanoff is a fugitive for violating the Sokovia Accords.[N 1] She escapes from U.S. Secretary of State Thaddeus Ross and flees to a safehouse in Norway set up by Rick Mason. Meanwhile, Belova kills a rogue former Black Widow, only to come in contact with a substance called Red Dust that removes her from the Red Room's mind control. She sends the antidote to Romanoff hoping she will return to help Belova free the other Widows. When Romanoff unknowingly drives off with the antidote, she is attacked by Taskmaster, who is after the Red Dust. Romanoff manages to evade Taskmaster and learns that the Dust came from Belova. The two reunite in Budapest, duel to a truce, and then are attacked by Black Widows. Romanoff learns Dreykov is still alive and the Red Room is still active. Romanoff and Belova evade the Widows and Taskmaster before meeting Mason, who supplies them with a helicopter. Romanoff and Belova break Shostakov out of prison to learn Dreykov's location. He tells them to speak with Vostokoff, who lives on a farm in Russia, where she developed the mind control process used on the Widows. There, Belova reveals that while they were not a real family, she believed they were so. Vostokoff gives away their location to Dreykov, whose agents arrive and take them to the Red Room, an aerial base. As Vostokoff and Romanoff used face mask technology to switch places before being captured, Vostokoff is able to help free Shostakov, Belova and herself from their restraints, while a disguised Romanoff confronts Dreykov. Romanoff learns Taskmaster is Antonia, who suffered damage so severe that Dreykov had to put a chip in her head, turning her into the perfect soldier. Romanoff attempts to kill Dreykov, but fails to harm him due to a pheromone lock he has installed in every Widow. Dreykov reveals that he controls Widows worldwide via his desk console. Romanoff intentionally breaks her nose, severing a nerve in her nasal passage to negate the pheromone and then attacks Dreykov. Shostakov battles Antonia, while Vostokoff attempts to take out the ship's engine and Belova searches for the other Widows, who are sent to protect Dreykov. Together, Shostakov and Belova lock Antonia in a secure room. Dreykov escapes as the Widows attack Romanoff, but Belova creates a Red Dust bomb that releases the Widows from mind control. Romanoff gets into the control desk and copies the locations of the other Widows worldwide just as the ship begins to explode and fall. Before leaving the control room, Romanoff picks up the two surviving vials of Red Dust, and then frees Antonia from the locked room. Vostokoff and Shostakov escape via a plane just as Belova takes out Dreykov's escape ship, killing him. Romanoff gives Belova a parachute before battling Antonia through the sky. After landing, Romanoff uses a vial of Red Dust on Antonia, freeing her from servitude. The freed Widows arrive as Belova, Vostokoff, and Shostakov say goodbye to Romanoff. She gives Belova the last Red Dust vial and the portable drive, telling her to find and free the other, still mind-controlled, Widows. As they leave with Antonia, Romanoff awaits Ross and his men, who have arrived to apprehend her. Two weeks later, Romanoff reunites with Mason, who supplies her with a quinjet. She leaves, intending to free the detained Avengers on the Raft. In a post-credits scene set after Romanoff's death,[N 2] Belova encounters Contessa Valentina Allegra de Fontaine at Romanoff's grave and receives her next assignment: take down Clint Barton, the man "responsible" for Romanoff's death.

Ray Thompson, a narcotics cop recently back on duty after a suspension, receives a package at the station. This leads to a website that shows a madman holding a child hostage. The child has timed explosives strapped to his body. Lt. Cronin arranges to pay the $2,000,112.35 ransom demanded by this criminal and makes Ray the bagman. When the exchange is bungled, Ray shoots and kills the madman before he sets the explosives off. Ray has to team up with Internal Affairs agent Julia Baker to locate the child before it's too late.[

Two years after anarchist Solomon Lane's capture, the remnants of his organization of rogue clandestine operatives, the Syndicate, continue to wreak havoc around the globe and have reorganized as a terrorist group known as the Apostles. They are allied with a mysterious extremist known as John Lark, who wrote a manifesto calling for the destruction of the current world order. At a safe house in Belfast, IMF agent Ethan Hunt is assigned to buy three stolen plutonium cores in Berlin from Eastern European gangsters, before the Apostles can. He is joined by Benji Dunn and Luther Stickell for the mission, but the team fails when Stickell is captured. Hunt's attempt to save Stickell allows agents of the arms dealer Alanna Mitsopolis (aka the White Widow) to seize the plutonium. The IMF team later captures nuclear weapons expert Nils Delbruuk, whose security clearance was revoked due to his anti-religious bigotry, and who designed nuclear bombs for the Apostles. Delbruuk explains the Apostles' credo that "there has never been great peace without first a great suffering. The greater the suffering, the greater the peace." Using a fake broadcast of Dunn posing as CNN's Wolf Blitzer, they trick Delbruuk into unlocking a phone that he used to communicate with Lark. Furious at the IMF's failure to secure the plutonium, CIA Director Erika Sloane instructs Special Activities Division operative August Walker to shadow Hunt as he attempts to retrieve it. Hunt and Walker infiltrate a nightclub party in Paris where Lark is believed to be buying the cores from Mitsopolis, who is acting as the middleman in the sale of the plutonium. They track a man whom they suspect to be Lark, but after fighting him in a restroom, the man is killed by MI6 agent Ilsa Faust. Hunt assumes the role of Lark without a disguise and escapes from hitmen sent to kill both Lark and Mitsopolis. In exchange for the plutonium, Mitsopolis tasks Hunt with extracting Lane from an armored convoy moving through Paris. She provides one of the plutonium cores as a down payment. To prevent Mitsopolis and her brother Zola from killing local police, Hunt and Walker preemptively attack the convoy. Ramming Lane's vehicle into water, they lead police and Mitsopolis's men on a chase across Paris while Dunn and Stickell, in a watercraft, secure Lane. Faust reappears and attempts to kill Lane to prove her loyalty to MI6, but the extraction is successful. Mitsopolis instructs Hunt to deliver both Lane and Faust to London. At a London safe house, IMF Secretary Alan Hunley reveals evidence doctored by Walker and passed to Sloane, stating Hunt is the real Lark. Eventually, Hunt, the team, and Hunley trick Walker into admitting he is the real Lark and inform Sloane, who sends in a CIA unit to take everyone into custody for transfer to Washington, D.C. However, the CIA unit had been infiltrated by the Apostles, and Walker orders the infiltrators to attack, killing every other operator in the CIA unit. Walker kills Hunley and escapes after Hunt chases him across London. As he departs for India with Lane, Walker instructs Hunt to turn himself in and admit that he is Lark or else Hunt's ex-wife Julia will be harmed. The team deduces that Lane and Walker plan to detonate the remaining two nuclear bombs at a medical camp over the Siachen Glacier, contaminating the water supply of India, Pakistan, and China; with a third of its population affected, the world will descend into an anarchy from which the Apostles hope a new world order will emerge. As the bombs are linked by a failsafe, any attempt to defuse one bomb without the detonator automatically triggers the other. Upon arrival in Kashmir, Hunt discovers Julia and her new husband Erik are assigned to the medical camp, an arrangement made by Walker to increase the pressure on Hunt. Lane programs the bombs' detonator with a 15-minute countdown and gives it to Walker, choosing to remain behind with the bombs. Walker takes off, secretly pursued by Hunt while Dunn, Stickell, and Faust try to find and defuse the nuclear weapons. Stickell attempts to deactivate the first bomb with Julia's help, but they are unable to without the detonator. Faust and Dunn find the second bomb and are ambushed by Lane and subdue him after an intense fight. Following an aerial chase, Hunt uses a commandeered helicopter to ram Walker's helicopter out of the sky. After a fight on a cliff, Walker is killed. Hunt then secures the detonator, allowing the team to deactivate the nukes. In the aftermath, Sloane hands Lane over to MI6 through Mitsopolis, with Faust earning her exoneration. Julia tells Hunt that he has given her the best life, despite his commitment to the IMF. Faust and the team join Hunt in celebration.