Leung has declined to discuss funding for the film except to state that funders came from "all over the world". In the film, Leung interviews a range of scientists and AIDS denialists, most notably Christine Maggiore. At the time of filming, Maggiore was HIV-positive and appeared healthy, despite her refusal to take anti-retroviral medication, which mainstream medicine uses to slow down the rate at which HIV destroys CD4+ T-cells. As she said in the film, she refused to take the medication and did not have her daughter, Eliza Jane Scovill, tested, or provide her with medication, because she believed HIV did not cause AIDS. Rather, she believed that the medication itself caused AIDS. Maggiore's relative health, despite years of infection, is used by the film to support the idea that anti-retrovirals are unnecessary to combat, and may themselves cause, AIDS. Maggiore would die due to complications caused by advanced untreated AIDS. The film's promotion of AIDS denialism, a pseudoscientific movement implicated in thousands of deaths, drew criticism and anger. The New York Times characterized the film as "a weaselly support pamphlet for AIDS denialists", "willfully ignorant", and "a globe-trotting pseudo-investigation that should raise the hackles of anyone with even a glancing knowledge of the basic rules of reasoning." The Wall Street Journal cited the film as part of "this season's fashion in conspiracy theories." The Portland Oregonian criticized Leung for "not being entirely honest with viewers," and decried the film's reliance on "selective editing, anomalies and anecdotes, unsupported conclusions... and suppression of inconvenient facts." Reaction from the scientific community was similarly negative. Lancet Infectious Diseases criticized the film's arguments, calling them a "toxic combination of misrepresentation and sophistry." AIDSTruth.org, a website created by HIV researchers to address AIDS denialism, criticized the film for concealing its "agenda behind a false veneer of honest inquiry", and published a rebuttal to some of the film's claims. Ben Goldacre, writing in The Guardian, described House of Numbers as "a dreary and pernicious piece of Aids denialist propaganda."

The Social Dilemma is a 2020 American docudrama film directed by Jeff Orlowski and written by Orlowski, Davis Coombe, and Vickie Curtis. It goes into depth on how social media's design is meant to nurture an addiction, manipulate people and governments, and spread conspiracy theories and disinformation. The film also examines the issue of social media's effect on mental health (including the mental health of adolescents and rising teen suicide rates). The film features interviews with many former employees, executives, and other professionals from top tech companies and social media platforms such as Facebook, Google, Twitter, Mozilla, and YouTube. These interviewees draw on their primary experiences at their companies to discuss how such platforms have caused negative problematic social, political, and cultural consequences. Some of the interviewees qualify that social media platforms and big tech companies have provided some positive change for society as well. These interviews are presented alongside scripted dramatizations of a teenager’s social media addiction.