Random COVID Questions with Dr. Been (#84)
Let’s discuss your COVID questions.
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Europe, Asia, Africa, ME - COVID Questions with Dr. Been (#22)
India’s current COVID is pretty bad. Will focus on this situation today. And, let’s also discuss the possible answers to your questions about COVID
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Reference links to review
Bloomberg Vaccination Tracker
https://www.bloomberg.com/graphics/covid-vaccine-tracker-global-distribution/
India approves Virafin
Zydus Cadila's Virafin Approved For Treating Moderate COVID-19 Cases
India COVID cases
https://www.worldometers.info/coronavirus/country/india/
https://www.covid19india.org/
https://www.covid19india.org/state/MH
https://www.covid19india.org/state/UP
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(Jan 21st, 2022) My COVID Status
Today's status. Hopefully last day of the status as I feel much better even without meds.
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
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Soluble Spike Proteins by Adenovirus Vaccines?
A pre-print study has caused a lot of sensation for two reasons. One, that it proves how Adenovirus based vaccines especially AstraZeneca causes clotting. And, second that it shows how the spike proteins are found in the blood. Let’s review this study.
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Pre-print
https://www.researchsquare.com/article/rs-558954/v1
PDF of the hypothesis/pre-print
https://assets.researchsquare.com/files/rs-558954/v1/8c30a186-e9e2-47c1-a76c-dc3bdf10c22a.pdf
What has to happen to prove this hypothesis?
1. Incorrect gene splicing has to occur. If not then the rest is not going to work.
2. Spike protein has to be built, but not have the anchoring part.
3. Spike protein has to be soluble, or part of it has to become soluble.
4. It has to be secreted but not able to attach on the surface of the cell.
5. Vaccine has to fail in producing neutralizing antibodies. (Mobeen, spike protein antibodies of any sort that can bind with this free and soluble spike protein.)
6. It has to enter the blood stream safely. Without getting phagocytosed. And, move through the capillary gap junctions.
7. It has to end up in the blood stream, and then combine with ACE2 as well. However, it has to not combine with the ACE2 in the local tissue where these were actually released.
8. Now this combination should be attacked by the antibodies resulting in the local inflammation. But, did we not say that these proteins got out and floated about because there was no antibody to bind to them? So, why there are antibodies binding now when the protein is in the blood?
9. Now, also, the NK cells will attack this complex causing local inflammation. They also need antibodies to be bound to this soluble protein.
10. Complement will also become activated by the Fc receptors. Attracting C3b or activating the complement cascade.
Reference:
https://en.wikipedia.org/wiki/Antibody-dependent_cellular_cytotoxicity
Profiles of current COVID-19 vaccines | SpringerLink
https://en.wikipedia.org/wiki/N-terminus
https://www.janssen.com/
https://www.janssencovid19vaccine.com/hcp/how-its-designed.html#
https://www.modernatx.com/moderna-blog/shedding-light-our-prophylactic-vaccines-moa
https://www.sciencedirect.com/science/article/pii/S0169409X2100003X
https://en.wikipedia.org/wiki/Antibody-dependent_cellular_cytotoxicity
https://en.wikipedia.org/wiki/N-terminus
https://en.wikipedia.org/wiki/RNA_splicing
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Macrophage, a central player in inflammation, innate and acquired immunity.
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Dr. Mobeen presents a review of immunology.
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Your COVID-19 Questions Answered (Open Forum Saturday Jan 23rd 2021)
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Link to the twitter thread with the questions
https://twitter.com/drbeen_medical/status/1352004651923640321?s=20
What protects our DNA from degradation?
jhttps://www.technologynetworks.com/genomics/news/how-the-cell-protects-dna-from-degradation-310243
Amino Acids to Codons
http://fourier.eng.hmc.edu/bioinformatics/intro/node7.html
Spike proteins amino acids and base pairs
https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-020-02448-z/figures/1
SARS-COV-2 genetics
https://www.nature.com/articles/s41401-020-0485-4
An epitope’s size
https://en.wikipedia.org/wiki/Epitope
What is an epitope?
https://en.wikipedia.org/wiki/Epitope
A good article about the mutations, variants, and strains
https://jamanetwork.com/journals/jama/fullarticle/2775006
If the virus mutates its spike proteins to look like ACE I and II enzymes, will it escape our immunity? (Yes)
https://www.frontiersin.org/articles/10.3389/fcimb.2020.00317/full
What causes fatigue, myalgia, etc., in the long haulers?
https://www.medicalnewstoday.com/articles/326619#symptoms
Virus may cause a hit and run outcome on the immune system
https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-018-1644-y
Are there inactivated virus vaccines for COVID?
https://www.thelancet.com/article/S1473-3099(20)30843-4/fulltext
Some side-effects of Ivermectin
https://www.medicalnewstoday.com/articles/ivermectin-oral-tablet
How do DNAses work?
https://www.sciencedirect.com/science/article/pii/S0012160617302221
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This lecture presents the immunoglobulin types, their functions, and comparative differences.
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