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27 May 2020 13:47:14 UTC
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Bradykinin | Let the Drama begin!
??Animated Mnemonics (Picmonic): https://www.picmonic.com/viphookup/medicosis/

- With Picmonic, get your life back by studying less and remembering more. Medical and Nursing students say that Picmonic is the most comprehensive and effective way to bridge learning and test prep...
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►?‍??Antibiotics Lectures: https://www.medicosisperfectionalis.com/products/courses/antibiotics/ ... Check out my brand new "Electrolytes" course at https://www.medicosisperfectionalis.com/products/course/electrolytes/ and use the PROMO code: ELECTROLYTES50 to get a 50% discount. Bradykinin is produced from high molecular weight kininogen (HMWK) via plasma kallikrein.
High molecular weight kininogen is a plasma protein (alpha globulin) responsible for activating the intrinsic coagulation pathway as well as producing the inflammatory mediator known as bradykinin (via plasma kallikrein).

Plasma kallikrein, in addition to high molecular weight kininogen (HMWK), is responsible for activating factor XII into XIIa.

Kallikrein-Kinin system consists of a kallikrein (plasma kallikrein or tissure kallikrein) producing a kinin (bradykinin in the plasma and kallidin in the tissue).

Angiotensin-converting enzyme (ACE) degrades bradykinin into inactive metabolites.

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Don't forget, bradykinin is a pro-inflammatory mediator that causes vasodilation and increases vessel permeability (leading to angioedema). When you use ACE inhibitors, bradykinin increases. If you like my videos, please consider leaving a tip at https://www.paypal.me/perfectionalis/
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