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6 Feb 2024 20:57:28 UTC
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DMT & 5-MeO-DMT: Pharmacology, effects, endogenous production
Psychedelic science father-son duo David & Charles NIchols talk about DMT and 5-MeO-DMT, including how they work in the brain and their pharmacological differences.
More content on the science of psychedelics:
[ https://substack.com/search/psychedelics?focusedPublicationId=513528&searching=focused_posts ]
LEARN MORE & SUPPURT M&M:
All M&M content, including podcast episodes & written content, is available on Substack. I mainly respond to questions & comments on that channel:
[ https://mindandmatter.substack.com ]
If you enjoy M&M content and want to provide further support, read this:
[ https://mindandmatter.substack.com/p/how-to-support-mind-and-matter ]
ABOUT Nick Jikomes:
Nick is a neuroscientist and podcast host. He is currently Director of Science & Innovation at a technology startup in the legal cannabis industry. He received a Ph.D. in Neuroscience from Harvard University and a B.S. in Genetics from the University of Wisconsin-Madison.
#psychedelics #medicine #science #podcast #neuroscience #chemistry #DMT #psilocybin #LSD #ketamine #psychiatry #depression #MDMA #ayahuasca #biology #health #mentalhealth
...
https://www.youtube.com/watch?v=2t-2IiEVgqc
More content on the science of psychedelics:
[ https://substack.com/search/psychedelics?focusedPublicationId=513528&searching=focused_posts ]
LEARN MORE & SUPPURT M&M:
All M&M content, including podcast episodes & written content, is available on Substack. I mainly respond to questions & comments on that channel:
[ https://mindandmatter.substack.com ]
If you enjoy M&M content and want to provide further support, read this:
[ https://mindandmatter.substack.com/p/how-to-support-mind-and-matter ]
ABOUT Nick Jikomes:
Nick is a neuroscientist and podcast host. He is currently Director of Science & Innovation at a technology startup in the legal cannabis industry. He received a Ph.D. in Neuroscience from Harvard University and a B.S. in Genetics from the University of Wisconsin-Madison.
#psychedelics #medicine #science #podcast #neuroscience #chemistry #DMT #psilocybin #LSD #ketamine #psychiatry #depression #MDMA #ayahuasca #biology #health #mentalhealth
...
https://www.youtube.com/watch?v=2t-2IiEVgqc
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video/mp4
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English
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VIDEO
ORIGI
origins-function-of-mitochondria
Dr. Andrew Dillin discusses the amazing world of mitochondria and their vital role in your body. Join us as we delve into their functions beyond energy production, exploring their evolutionary origins and symbiotic relationship with cells. Uncover the intriguing story behind this biological marvel.
Clip from this podcast conversation: https://mindandmatter.substack.com/p/early-access-cell-biology-of-aging
#Mitochondria #Biology #Science #CellBiology #Metabolism #Aging #Podcast
...
https://www.youtube.com/watch?v=a-1S3r3UWCM
Transaction
Created
3 weeks ago
Content Type
Language
video/mp4
English
Controlling
VIDEO
MICHA
michael-crair-brain-development,
Nick talks to physicist and neuroscientist Dr. Michael Crair. Michael runs a lab at Yale University studying mechanisms of brain development. He discussed research related to neural plasticity, learning & memory, sensory maps, and critical periods of plasticity. Dr. Crair also described recent findings from his lab show that parts of the developing brain can simulate future sensory experiences, before animals ever open their eyes and see the external world.
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Learn more about our podcast sponsor, Dosist
[https://dosist.com/]
ABOUT Nick Jikomes:
Nick is a neuroscientist and podcast host. He is currently Director of Science & Innovation at Leafly, a technology startup in the legal cannabis industry. He received a Ph.D. in Neuroscience from Harvard University and a B.S. in Genetics from the University of Wisconsin-Madison.
0:00:00 Episode Intro
0:04:49 Michael Crair Intro
0:06:55 Sensory Maps in the Brain
0:13:02 Developmental Plasticity
0:21:11 Spontaneous Brain Activity
0:25:01 Dreaming & Simulation
0:34:42 Techniques For Studying the Brain
0:41:39 Activity Patterns in the Brain
0:50:00 Human Brain Development
0:59:10 Psychiatric Disorders & Neuroplasticity
1:05:44 Technology's Impact on Brain Development
1:11:41 Brain & Mental Health Habits
1:15:00 Final Thoughts
...
https://www.youtube.com/watch?v=GNcyfyBtbu8
Transaction
Created
1 year ago
Content Type
Language
video/mp4
English
Controlling
VIDEO
THE P
the-phytochemical-diversity-of
Nick Jikomes, PhD gives a talk summarizing a research project between Leafly, the University of Colorado-Boulder, and several cannabis testing laboratories in the United States. The talk summarizes the findings of a research study (link below) about the chemical diversity of commercial cannabis flower across six US states.
The research Nick discusses examines questions related to the cannabinoid and terpene content of commercial cannabis, as well as how well commercial labeling systems (Indica/Sativa, "strain names") relate to the underlying chemical profile of the cannabis products they're attached to.
Full study (preprint): https://www.biorxiv.org/content/10.1101/2021.07.05.451212v1.abstract
The talk was put on by The Technology Alliance is a non-profit organization of leaders from Washington’s innovation-based businesses and research institutions united by the vision of a vibrant innovation economy that benefits all of our state's citizens. The Technology Alliance produces a monthly lecture series whose mission is to illuminate the game-changing, life-altering, research that is being done in Washington state with the goal of increasing public support for that research.
...
https://www.youtube.com/watch?v=KnBkWQr1rtc
Transaction
Created
1 year ago
Content Type
Language
video/mp4
English
Controlling
VIDEO
PLANT
plant-based-foods,-plant-protein,-anti
Metabolic psychiatrist Dr. Georgia Ede discusses plant- vs. animal-based foods, including: bioavailability of plant proteins, nutrients vs. anti-nutrients, plant toxins, and more.
Clip from this podcast conversation: https://mindandmatter.substack.com/p/diet-nutrition-metabolic-psychiatry
#Diet #Metabolism #Nutrition #Biology #Science #Psychiatry #Medicine #Food #Podcast
...
https://www.youtube.com/watch?v=vUW57hM4QqU
Transaction
Created
1 month ago
Content Type
Language
video/mp4
English
Controlling
VIDEO
HOW T
how-to-get-into-ketosis-fastest-and
Dr. Georgia Ede talks about the key factors that stimulate insulin response in the body and how to bring your insulin levels down to reach the fat-burning state of ketosis. Discover the fastest and safest methods to burn fat effectively.
Clip from this podcast conversation: https://mindandmatter.substack.com/p/diet-nutrition-metabolic-psychiatry
#Diet #Science #Biology #Metabolism #Ketosis #Fat #Insulin #Health #Nutrition #Fitness #WeightLoss #KetogenicDiet
...
https://www.youtube.com/watch?v=Or4RQ1uObGI
Transaction
Created
3 weeks ago
Content Type
Language
video/mp4
English
Controlling
VIDEO
PSYCH
psychology-of-stress,-resilience,
About the guest: Stephen Sideroff, PhD is a clinical psychologist and Associate Professor of Psychiatry and Behavioral Sciences at UCLA. His new book is, "The 9 Pillars of Resilience."
Episode summary: Nick and Dr. Sideroff discuss: childhood & developmental psychology; clinical & Gestalt psychology; stress & resilience; pharmaceuticals, talk therapy, and plant medicines; emotions & psychopathology; and more.
*This content is never meant to serve as medical advice.
All M&M content, including podcast episodes & written content, is available on Substack. I mainly respond to questions & comments on that channel:
[ https://mindandmatter.substack.com ]
If you enjoy M&M content and want to provide further support, read this:
[ https://mindandmatter.substack.com/p/how-to-support-mind-and-matter?utm_source=%2Fsearch%2Fsupport&utm_medium=reader2 ]
ABOUT Nick Jikomes:
Nick is a neuroscientist and podcast host. He is currently Director of Science & Innovation at a technology startup in the legal cannabis industry. He received a Ph.D. in Neuroscience from Harvard University and a B.S. in Genetics from the University of Wisconsin-Madison.
#Science #Podcast #Biology #Evolution #Diet #Genetics #Genomics #HumanEvolution #Anthropology #Disease
0:00:00 Intro
0:02:25 Stephen Sideroff conversation
...
https://www.youtube.com/watch?v=jaJ-qwO-8SA
Transaction
Created
3 weeks ago
Content Type
Language
video/mp4
English
Controlling
VIDEO
M&M C
m-m-clips-genes-from-neanderthals,
Paleoanthropologist describes interbreeding between Neanderthals and ancient humans, genes humans got from Neanderthals, and the role some of those genes plan in immunity and COVID risk today.
Learn more about this episode's sponsor, Dosist: https://dosist.com/
Support the podcast: https://www.patreon.com/nickjikomes
Connect with Nick Jikomes on Twitter:
https://twitter.com/trikomes
Download the podcast & follow Nick:
https://nickjikomes.com
About Nick Jikomes:
Nick is a neuroscientist and podcast host. He is currently Director of Science & Innovation at Leafly, the world's largest cannabis information resource. He received a Ph.D. in Neuroscience from Harvard University and a B.S. in Genetics from the University of Wisconsin-Madison.
...
https://www.youtube.com/watch?v=KhFSJ3_NemI
Transaction
Created
1 year ago
Content Type
Language
video/mp4
English
Controlling
VIDEO
THE P
the-paleo-diet-what-a
Paleoanthropologist Dr. Eugene Morin gives his take on the modern "Paleo diet" trend.
...
https://www.youtube.com/watch?v=eqWX5FUE4h8
Transaction
Created
1 day ago
Content Type
Language
video/mp4
English
Controlling
VIDEO
CHARL
charles-nichols-psychedelics,
Charles Nichols, Ph.D. is a professor of pharmacology at Louisiana State University. He has been studying the molecular, genetic, and behavioral effects of psychedelics for nearly 25 years and is considered one of the world’s top experts on their biological effects.
Learn more about this episode's sponsor, Dosist: https://dosist.com/
Support the podcast: https://www.patreon.com/nickjikomes
Connect with Nick Jikomes on Twitter:
https://twitter.com/trikomes
Download the podcast & follow Nick:
https://nickjikomes.com
About Nick Jikomes:
Nick is a neuroscientist and podcast host. He is currently Director of Science & Innovation at Leafly, the world's largest cannabis information resource. He received a Ph.D. in Neuroscience from Harvard University and a B.S. in Genetics from the University of Wisconsin-Madison.
0:00 Intro
1:18 What are psychedelics?
4:45 Psychedelic tryptamines & serotonin
8:46 The psychedelic brain receptor
13:43 Natural functions of serotonin & 5HT2A
18:15 Effect of psychedelics on brain activity
20:33 Neurogenesis & depression
24:10 Psychedelic effects vs. therapeutic effects
26:32 Psilocybin vs. ketamine for depression
28:21 Giving rats & mice psychedelics
32:52 Psychotherapy & plasticity
36:00 Long- vs. short-lasting psychedelics
38:16 How Charles got into psychedelic science
45:18 Psychedelics, inflammation, and the body
49:25 DOI, a potent psychedelic & anti-inflammatory
52:01 Psychedelics as an asthma treatment
58:46 Microdosing
1:02:06 Brain inflammation & psychiatric disorders
1:08:08 Doing science on Schedule I drugs
1:14:33 Psychedelics & psychosis
1:17:53 Are psychedelics non-toxic?
1:20:10 Scientist in an LSD study in the 60s
1:24:40 DMT facts & myths
1:33:38 Most exciting upcoming research
1:38:11 Psychedelic startups & new drug formulations
1:44:42 The future of psychedelic research
1:48:42 Final thoughts
...
https://www.youtube.com/watch?v=hqYpMx32Z3E
Transaction
Created
1 year ago
Content Type
Language
video/mp4
English