Ashwagandha is an herb that has been used in Indian (Ayurvedic) medicine for nearly 3000 years. It is found in India (native), the Middle East, and Africa. It is reported to have anti-inflammatory, anti-microbial, anti-diabetic, anti-hypertensive, neuroprotective, apoptogenic, and reproductive and hormone-modulating effects. In this episode, we will review the anti-inflammatory aspects of ashwaganda and specifically, will discuss NF-kB pathway modulation. URL list from Thursday, July 20, 2023 Home - FLCCC | Front Line COVID-19 Critical Care Alliance https://covid19criticalcare.com/ Pharmaceutics | Free Full-Text | Ashwagandha (Withania somnifera)—Current Research on the Health-Promoting Activities: A Narrative Review https://www.mdpi.com/1999-4923/15/4/1057 Ashwagandha - Special Subjects - Merck Manuals Consumer Version https://www.merckmanuals.com/home/special-subjects/dietary-supplements-and-vitamins/ashwagandha Ashwagandha root extract exerts anti‑inflammatory effects in HaCaT cells by inhibiting the MAPK/NF‑κB pathways and by regulating cytokines https://www.spandidos-publications.com/ijmm/42/1/425 Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study | Signal Transduction and Targeted Therapy https://www.nature.com/articles/s41392-020-00312-6 Frontiers | NF-κB Signaling in Macrophages: Dynamics, Crosstalk, and Signal Integration https://www.frontiersin.org/articles/10.3389/fimmu.2019.00705/full fimmu-10-00705-g002.jpg (1084×813) https://www.frontiersin.org/files/Articles/443978/fimmu-10-00705-HTML/image_m/fimmu-10-00705-g002.jpg fimmu-10-00705-g001.jpg (1084×813) https://www.frontiersin.org/files/Articles/443978/fimmu-10-00705-HTML/image_m/fimmu-10-00705-g001.jpg Frontiers | What Is Nuclear Factor Kappa B (NF-κB) Doing in and to the Mitochondrion? https://www.frontiersin.org/articles/10.3389/fcell.2019.00154/full#:~:text=Nuclear%20factor%20kappa%20B%20(NF%2D%CE%BAB)%20is%20an%20ancient,cellular%20resistance%20to%20invading%20pathogens IκBα - Wikipedia https://en.wikipedia.org/wiki/I%CE%BAB%CE%B1 Disclaimer: This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only. Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.

Studies show that neurons are metabolically protected when low dose Methylene Blue is administered systemically. Methylene Blue promotes energy metabolism and neuronal survival. A similar protective effect is observed with near infrared light. Let's review. DrBeen: Medical Education Online https://www.drbeen.com/ FLCCC | Front Line COVID-19 Critical Care Alliance https://covid19criticalcare.com/ References URL list from Thursday, Nov. 10 2022 Frontiers | Protection against neurodegeneration with low-dose methylene blue and near-infrared light https://www.frontiersin.org/articles/10.3389/fncel.2015.00179/full Methylene Blue Reduces Acute Cerebral Ischemic Injury via the Induction of Mitophagy | Molecular Medicine | Full Text https://molmed.biomedcentral.com/articles/10.2119/molmed.2015.00038 Effect of Methylene Blue on White Matter Injury after Ischemic Stroke - PMC https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7872771/ Repurposing methylene blue in the management of COVID-19: Mechanistic aspects and clinical investigations - PMC https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8352658/ Frontiers | Methylene Blue Reduces Neuronal Apoptosis and Improves Blood-Brain Barrier Integrity After Traumatic Brain Injury https://www.frontiersin.org/articles/10.3389/fneur.2019.01133/full Addressing Personal Protective Equipment (PPE) Decontamination: Methylene Blue and Light Inactivates SARS-CoV-2 on N95 Respirators and Masks with Maintenance of Integrity and Fit | medRxiv https://www.medrxiv.org/content/10.1101/2020.12.11.20236919v2.full Mitochondria as a target for neuroprotection: role of methylene blue and photobiomodulation https://translationalneurodegeneration.biomedcentral.com/articles/10.1186/s40035-020-00197-z Photobiomodulation as a treatment for neurodegenerative disorders: current and future trends - PMC https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694374/ Shining light on the head: Photobiomodulation for brain disorders - PMC https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066074/ Nitric Oxide, Cytochrome C Oxidase, and the Cellular Response to Hypoxia | Arteriosclerosis, Thrombosis, and Vascular Biology https://www.ahajournals.org/doi/10.1161/ATVBAHA.108.181628 Mitochondrial electron transport chain, ROS generation and uncoupling (Review) https://www.spandidos-publications.com/10.3892/ijmm.2019.4188#:~:text=The%20sites%20of%20ROS%20production,peroxide%20(48%2C49). Frontiers | Mitochondrial Reactive Oxygen Species and Their Contribution in Chronic Kidney Disease Progression Through Oxidative Stress https://www.frontiersin.org/articles/10.3389/fphys.2021.627837/full#:~:text=Mitochondrial%20reactive%20oxygen%20species%20are,et%20al.%2C%202013). Mitochondria—Fundamental to Life and Health - PMC https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684129/ After Treatment with Methylene Blue is Effective against Delayed Encephalopathy after Acute Carbon Monoxide Poisoning - PubMed https://pubmed.ncbi.nlm.nih.gov/29151273/ Disclaimer: This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only. Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.