?Subscribe for more content: https://www.youtube.com/@LisaTamatiCoach ▶️ Full interview: https://youtu.be/8962UXt8D24 In this episode with a luminary in the longevity and anti-aging research world, Professor Joseph Baur, we discuss his lab's current state of research on NAD metabolism and its impact on aging. Going beyond the popular theories around NMN and NR supplementation, we dive deep into the biochemistry of how these compounds work, what we know and don't yet know, and what strategies we may want to deploy based on the latest research to slow our own aging trajectory and improve our health. We discuss: ◾What NAD is and its roles in the body. ◾NAD's role in redox cycling. ◾Its role with Sirtuin genes and PARPs. ◾The impact of a decline in the rate-limiting NAMPT enzyme as we age ◾How we might possibly impact and upregulate this enzyme. ◾How the NMNT enzyme could lead to methyl donor depletion. ◾The three pathways associated with NAD production ◾Differences btn Nicotinamide Riboside and Nicotinamide Mononucleotide as NAD precursors. ◾How the gut microbiome plays a part. ◾The problem with translating findings from mouse models to humans If you are looking for NMN, Quercetin, TMG, or other products after listening to this episode, make sure to check out my curated range of longevity and anti-aging supplements at the cutting edge of science at www.lisatamati.com. ? Professor Joseph Baur Bio Joseph Baur earned his Ph.D. from the University of Texas Southwestern Medical Center in Dallas, Texas, where he studied mechanisms that limit the lifespan of cultured human cells under Drs. Jerry Shay and Woody Wright. He then moved to Harvard Medical School, where he trained as a postdoctoral fellow with Dr. David Sinclair. There, he developed a strong interest in the regulation of aging and metabolism by sirtuins, a conserved class of enzymes that require nicotinamide adenine dinucleotide (NAD) as a co-substrate. His lab currently studies metabolic and signaling pathways by which nutrient intake can influence longevity, with a particular emphasis on NAD and mTOR. Dr. Baur joined the faculty of the Perelman School of Medicine at the University of Pennsylvania, Institute for Diabetes, Obesity, and Metabolism, and the Department of Physiology. Baur Lab Website: www.med.upenn.edu/baurlab/index.html ------------------ ? Connect with Lisa: Website: www.lisatamati.com Instagram: https://www.instagram.com/lisatamati Facebook: https://www.facebook.com/lisatamati Twitter: https://linktr.ee/lisatamati Podcast - Pushing The Limits: https://www.lisatamati.com/podcast/ ⚠️Please participate in the survey to provide feedback on the podcast: https://www.lisatamati.com/survey/ One-on-One Health Coaching: https://www.lisatamati.com/health-opt... Lisa's Books: https://shop.lisatamati.com/collections/books Online Shop: Supplements https://shop.lisatamati.com/collections/anti-aging-and-longevity-supplements. Support this educational platform ? Lisa's Patron Community: https://patron.lisatamati.com/patron1 ☕ If you want to support Lisa with a "coffee" follow this link https://www.buymeacoffee.com/LisaT to donate $3 Please note the following medical disclaimer: By viewing this video you understand that this video is for educational purposes only. It is not intended to substitute for professional medical advice and should not be relied on as health or personal advice. Always seek the guidance of your doctor with any questions you may have regarding your health or medical condition. #Photobiomodulation#Longevity#brainhealth #lifeextension#podcast#neuromodulation# ... https://www.youtube.com/watch?v=ua04Lv5x9ms

We have all done it.. set out all excited on a new training regime or nutrition plan then become derailed by something, lost our way, fell off the proverbial bandwagon.  In this episode Ultra Endurance Athlete Lisa and Exercise Scientist Neil Wagstaff give their greatest tips for staying motivated, changing the stories running in your head, getting past limiting beliefs and changing your moods and emotions so you can stay focussed and reach those long-held dreams  We would like to thank our sponsors for this show: www.vielight.com Makers of Photobiomodulation devices that stimulate the brains mitocondria, the power houses of your brains energy, through infrared light to optimise your brain function. To get 10% off your order use the code: TAMATI at https://www.vielight.com For more information on Lisa Tamati's programs, books and documentaries please visit www.lisatamati.com For Lisa's online run training coaching go to https://runninghotcoaching.com/info44794896 Join hundreds of athletes from all over the world and all levels smashing their running goals while staying healthy in mind and body. Lisa's Epigenetics Testing Program https://www.peakwellness.co.nz/epigenetics measurement and lifestyle stress data, that can all be captured from the comfort of your own home For Lisa's Mental Toughness online course visit: https://www.lisatamati.com/page/mindsetu-mindset-university/ For Lisa's free weekly Podcast "Pushing the Limits" subscribe on iTunes or your favorite podcast app or visit the website https://www.lisatamati.com/podcast/ -------------------------------------------------------------------------------------------------------------------------------------------------------- Lisa's third book has just been released. It's titled "Relentless - How A Mother And Daughter Defied The Odds" Visit: https://relentlessbook.lisatamati.com/ for more Information ABOUT THE BOOK: When extreme endurance athlete, Lisa Tamati, was confronted with the hardest challenge of her life, she fought with everything she had. Her beloved mother, Isobel, had suffered a huge aneurysm and stroke and was left with massive brain damage; she was like a baby in a woman's body. The prognosis was dire. There was very little hope that she would ever have any quality of life again. But Lisa is a fighter and stubborn. She absolutely refused to accept the words of the medical fraternity and instead decided that she was going to get her mother back or die trying. This book tells of the horrors, despair, hope, love, and incredible experiences and insights of that journey. It shares the difficulties of going against a medical system that has major problems and limitations. Amongst the darkest times were moments of great laughter and joy. Relentless will not ... https://www.youtube.com/watch?v=rWwXp1y8aVM