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Vaccine Induced Clotting - How Will A Doctor Manage It?
Vaccine Induced Clotting - How Will A Doctor Manage It?
About six million doses administered. 6 women developed clotting. 1 died. 1 hospitalized in critical condition. Clots develop between 1 week to 3 weeks.
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FDA and CDC Statement
https://www.cdc.gov/media/releases/2021/s0413-JJ-vaccine.html
A German study provided good working model for this situation, but, associated with AstraZeneca
Study for AstraZeneca showing a possible relation of thrombotic thrombocytopenia to the vaccine. FDA and CDC suspect a similar relation to Janssen vaccine.
https://www.researchsquare.com/article/rs-362354/v1
Note: this is not a medical advice or prescription. The following information here and in the video that goes with this is for educational purposes only.
Don’t take any medicine without your doctor’s advice. These medicines can lead to death.
General clinical signs and symptoms
Persistent headache (severe,) shortness of breathe, leg pain, nose bleed, GIT pain, petechial hemorrhages under the skin, bruising under the skin, etc.
Thrombocytopenia within 5-10 days.
Platelet count dropping to 50% or more.
4T score: https://qxmd.com/calculate/calculator_113/hit-4t-s-score
Management
Management should start as soon as the diagnosis is suspected before the results from the labs are available.
Outdoor possible management.
Note, these patients must be referred to ICU/or call 911. Any wasted time can cause permanent damage.
Possible outdoor/supportive management as recommended by Prof., Greinacher et., al
Oral: Rivaroxaban, Apixaban, high dose IVIG
In Hospital and ICU
Direct thrombin inhibitors for prophylaxis and management
Argatroban IV is more important and urgent than the oral agents. Move to ICU.
Transition to warfarin or other anticoagulants (not Heparin) for 30 days when platelet count has recovered.
Labs
Normal platelet count is 150,000 to 450,000 per microliter of the blood.
Reference: healthy platelet count https://www.hopkinsmedicine.org/health/conditions-and-diseases/what-are-platelets-and-why-are-they-important
Enzyme immunoassay for heparin-induced thrombocytopenia/thrombosis are widely available
Platelet activation assays from the labs
Perform doppler of the lower extremities to rule out any thrombi in the legs
Get aPTT fort iterating argatroban
aPTT = activated partial thromboplastin time.
Reference for the platelet aggregation test molecular mechanisms
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578190/
Rivaroxaban https://en.wikipedia.org/wiki/Rivaroxaban
Apixaban https://en.wikipedia.org/wiki/Apixaban
Argatroban
...
https://www.youtube.com/watch?v=vBjDRwCJuNg
About six million doses administered. 6 women developed clotting. 1 died. 1 hospitalized in critical condition. Clots develop between 1 week to 3 weeks.
Buy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed
Become my patron: https://www.patreon.com/mobeensyed?fan_landing=true
Looking to support my educational work? Donate here: https://paypal.me/mobeensyed?locale.x=en_US
FDA and CDC Statement
https://www.cdc.gov/media/releases/2021/s0413-JJ-vaccine.html
A German study provided good working model for this situation, but, associated with AstraZeneca
Study for AstraZeneca showing a possible relation of thrombotic thrombocytopenia to the vaccine. FDA and CDC suspect a similar relation to Janssen vaccine.
https://www.researchsquare.com/article/rs-362354/v1
Note: this is not a medical advice or prescription. The following information here and in the video that goes with this is for educational purposes only.
Don’t take any medicine without your doctor’s advice. These medicines can lead to death.
General clinical signs and symptoms
Persistent headache (severe,) shortness of breathe, leg pain, nose bleed, GIT pain, petechial hemorrhages under the skin, bruising under the skin, etc.
Thrombocytopenia within 5-10 days.
Platelet count dropping to 50% or more.
4T score: https://qxmd.com/calculate/calculator_113/hit-4t-s-score
Management
Management should start as soon as the diagnosis is suspected before the results from the labs are available.
Outdoor possible management.
Note, these patients must be referred to ICU/or call 911. Any wasted time can cause permanent damage.
Possible outdoor/supportive management as recommended by Prof., Greinacher et., al
Oral: Rivaroxaban, Apixaban, high dose IVIG
In Hospital and ICU
Direct thrombin inhibitors for prophylaxis and management
Argatroban IV is more important and urgent than the oral agents. Move to ICU.
Transition to warfarin or other anticoagulants (not Heparin) for 30 days when platelet count has recovered.
Labs
Normal platelet count is 150,000 to 450,000 per microliter of the blood.
Reference: healthy platelet count https://www.hopkinsmedicine.org/health/conditions-and-diseases/what-are-platelets-and-why-are-they-important
Enzyme immunoassay for heparin-induced thrombocytopenia/thrombosis are widely available
Platelet activation assays from the labs
Perform doppler of the lower extremities to rule out any thrombi in the legs
Get aPTT fort iterating argatroban
aPTT = activated partial thromboplastin time.
Reference for the platelet aggregation test molecular mechanisms
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578190/
Rivaroxaban https://en.wikipedia.org/wiki/Rivaroxaban
Apixaban https://en.wikipedia.org/wiki/Apixaban
Argatroban
...
https://www.youtube.com/watch?v=vBjDRwCJuNg
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