How can cancer and cancer cells be understood through the lens of cellular metabolism, and what insights can be gained into various forms of treatment? Many studies suggest that metabolic changes and the environment in which the cells inhabit can significantly impact how they function. Listen in to learn: How cancer cells are affected by oxygen availability Some often-overlooked benefits of Chemotherapy How cellular metabolism and pathways can affect the development of cancer cells Oncologist and cancer researcher at the Koch Institute at MIT, Dr. Matthew Vander Heiden, shares his research experience and some surprising cellular processes that can dramatically impact cancer cells. Dr. Vander Heiden sheds light on the Warburg effect, which describes how cancer cells tend to uptake glucose and ferment it rather than burning it in respiration. The fermentation of glucose rather than respiration is revealed to be how FDG PET scans function by differentiating cancer cells that use more sugar and show up highlighted on the scan. The fermentation process ultimately produces ATP and lactate to fuel the cancer cell. Alongside development pathways for the cells, oxygen is also a limiting factor on cancer cells, and the lack or surplus will encourage particular pathways to be used. Due to the availability of particular nutrients in different regions of the body, it is also thought that an individual's diet can impact the development of cancer cells. This is explained the clustering and absorption of those nutrients at different concentrations throughout the body. For more information, visit https://ki.mit.edu. Episode also available on Apple Podcasts: apple.co/30PvU9C ... https://www.youtube.com/watch?v=SWOaEkkrSgE

Our Website: https://www.findinggeniuspodcast.com/ Subscribe and review our Podcast on iTunes: https://apple.co/2L6tN88 Follow us on: Facebook: https://web.facebook.com/futuretechpodcast/ Twitter: https://twitter.com/finding_genius Instagram: https://www.instagram.com/findinggeniuspodcast/ LinkedIn: https://www.linkedin.com/company/finding-genius-podcast/ What can big data and genomics offer the individual regarding medical treatment? Dr. Daniel Geschwind is here to explain exome sequencing data analysis as well as how this field might expand and progress. Listen and learn 1. What makes up our genome, how to understand the terms for each part, like exon, intron, and exome, and what parts are effected epigenetically; 2. Why genomics testing still focuses on that 2 to 3 percent of the genome called the exome that codes for proteins; and 3. How sequencing will broaden and change, making preventative care that much more effective for certain patients and more. Dr. Daniel Geschwind is the Gordon and Virginia MacDonald Distinguished Professor in Neurology, Psychiatry, and Human Genetics; the Senior Associate Dean and Associate Vice Chancellor for Precision Health at UCLA; and the director of the Center for Autism Research and Treatment at the Semel Institute at UCLA David Geffen School of Medicine. He opens up the world of genomics for listeners, explaining why an exome sequencing test is the center of precision medicine currently. He explains how the exome is composed of the 3% of your genome that actually codes for protein sequences. What's the rest of the genome up to? Well, scientists believe that remainder of your genome is busy regulating those sequences, determining levels and turning gene expressions on and off.  He explains how scientists use the exome sequencing process. In fact, the majority of people who say they've been sequenced mean, in fact, that their exome has been sequenced. Whole genome sequencing costs about three times as much but offers scientists the same information at this point. However, he thinks this will soon change. As the exome sequencing project continues and our knowledge accumulates, the benefits will increase from whole genome sequencing. The costs are likely to drop as well.  Once it gets inexpensive enough and we have sequenced hundreds of millions of patients with a variety of disorders, we will have much better predictive power.  For more information, he suggests UCLA's Precision Health website. Available on Apple Podcasts: apple.co/2Os0myK #genetics #genomics #Findinggeniuspodcast #geneexpression #sequencing #Healthpodcast #InternalMedicinepodcast #Biosciencespodcast ... https://www.youtube.com/watch?v=G7dmdbWyopA