Science-to-the-People---LA-SUPREMA-IMPORTANCIA-DE-LA-FIEBRE---Ernesto-Prieto-Gratacós-(26-12-2020)
La infame “tormenta de citoquinas”, causante del agravamiento de muchos pacientes de COVID, y de otras infecciones, sería una consecuencia iatrogénica del erróneo intento de bajar la fiebre con fármacos.
¿Por qué un mecanismo tan costoso para la economía corporal ha sido conservado en todas las especies a lo largo de la evolución? La evidencia científica muestra que la fiebre es inmensamente necesaria para armar una eficaz respuesta inmune, teniendo una relación riesgo/beneficio de 100 a 1, aportando a funciones de alto orden ligadas a la supervivencia.
Referencias:
- https://www.ernestoprietogratacos.com/post/rol-inmunoagonico-fiebre
- Fever in Ectotherms: Evolutionary Implications Matthew J. Kluger. Journal of American Zoology, 1979.
- Did pathogens facilitate the rise of endothermy? Logan ML. Ideas in Ecology and Evolution, 2019.
- Fever: Its Biology, Evolution, and Function. Matthew J. Kluger. Princeton University Press, 1979.
- Sickle Cell Anaemia and Malaria. Lucio Luzzatto Mediterr J Hematol Infect Dis. 2012
- Thermoregulation: some concepts have changed Functional architecture of the thermoregulatory system. Romanovsky AA. Am J Physiol Regul Integr Comp Physiol. 2007
- Adult survival, maturation, and reproduction of the desert locust Schistocerca gregaria infected with the fungus Metarhizium anisopliae var acridum. Blanford S, Thomas MB J Invertebr Pathol. 2001
- The Evolution and Adaptive Value of Fever Kluger, MJ. American Scientist, 1978.
- Mammalian endothermy optimally restricts fungi and metabolic costs. Bergman, A. & Casadevall, A. Journal American Society of Microbiology, 2010.
- Prokaryotic and eukaryotic heat shock proteins in infectious disease. Pockley AG, Calderwood SK, Santoro MG. Dordrecht: Springer; 2010.
- From protozoa to bacteria and viruses - Fifty years with microbes. Lwoff A. Annu Rev Microbiol, 1971
- Studies Relating to the Serum Resistance of Certain Gram-Negative Bacteria. Osawa E, Muschel LH. J Exp Med. 1964
- Fever and the thermal regulation of immunity: The immune system feels the heat. Evans, S. S., Repasky, E. A., & Fisher, D. T. (2015). Nature Reviews Immunology
- Fever management: Evidence vs current practice. Radhi, A. S. M. (2012).World Journal of Clinical Pediatrics
- Febrile seizures: a population-based study. Dalbem JS, Siqueira HH, Espinosa MM, Alvarenga RP. J Pediatr, 2015,
- The prevalence of epilepsy and other seizure disorders in an Arab population: a community-based study. Al Rajeh S, Awada A, Bademosi O, Ogunniyi A. Seizure. 2001
- Epilepsy in rural Kentucky: prevalence in a population of school age children. Baumann RJ, Marx MB, Leonidakis MG. Epilepsia. 1978
- Epidemiology of febrile seizures and epilepsy: a call for action. Pierre-Marie Preux, Voa Ratsimbazafy, Jeremy Jost. Journal de Pediatria, 2015.
- Fever in the leech, Nephelopsis obscura (Annelida). Michel Cabanac. Journal of Comparative Physiology B, 1989.
- Behavioral fever in ectothermic vertebrates. Krzysztof Rakus, Maygane Ronsmans, Alain Vanderplasschen. Developmental and comparative immunology, 2016.
- Thermoregulation as a disease tolerance defense strategy. Alexandria M. Palaferri Schieber and Janelle S. Ayres. Pathog Dis, 2016.
- Phylogeny of fever. Kluger MJ Fed Proc. 1979.
- Effect of drug-induced antipyresis on survival. H A Bernheim, M J Kluger. Science, 1976 Fever and antipyresis in the lizard Dipsosaurus dorsalis. Bernheim HA, Kluger MJ. Am J Physiol, 1976.
- Heat of Respiration of Injured and Diseased Leaves. Yarwood CE. Phytopathology, 1953.
- Behavioural fever in zebrafish larvae. Sonia Rey, Visila Moiche, Sebastian Boltaña, Mariana Teles, Simon MacKenzie. Dev Comp Immunol, 2017.
- Behavioural fever is a synergic signal amplifying the innate immune response. S. Boltaña, S. Rey, Sally Mackenzie et al. Proceedings of the Royal Society B: Biological Sciences, 2013.
- Regulation of thermogenesis in plants: the interaction of alternative oxidase and plant uncoupling mitochondrial protein. Zhu Y, et al. J Integr Plant Biol, 2011.
- Lower temperatures reduce type I interferon activity and promote alphaviral arthritis. Natalie A. Prow et al. PloS Pathog, 2017.
- Metabolic cost of shivering. Horvath SM, Spurr GB, Hutt BK, Hamilton LH. J Appl Physiol, 1956.
- Pathogenesis of Fever. Sahib El-Radhi. Clinical Manual of Fever in Children. 2019
- Thermal and PGE2 sensitivity of the organum vasculosum lamina terminalis region and preoptic area in rat brain slices. T Matsuda, T Hori, and T Nakashima J. Physiol, 1992.
Videos relacionados:
- https://odysee.com/@plandemia:9/PROTECCI%C3%93N_ANTIVIRAL_TOTAL-ErnestoPrieto_20210102:7
- https://odysee.com/@plandemia:9/ErnestoPrieto200328:f
- https://odysee.com/@plandemia:9/ErnestoPrieto200327:8
- https://odysee.com/@plandemia:9/EPrietoSuecia1:f
- https://odysee.com/@plandemia:9/ErnestoPrieto200408:b
- https://odysee.com/@plandemia:9/ErnestoPrieto200402:8
- https://odysee.com/@plandemia:9/ErnestoPrieto200422:d
- https://odysee.com/@plandemia:9
Transaction
Created
3 weeks ago
Content Type
Language
video/mp4
es