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10 Jun 2020 12:20:29 UTC
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Make p-Chlorophenyl Acetonitrile - Step 4 in Pyrimethamine Synthesis
In this video we make p-chlorophenyl acetonitrile from the p-chlorobenzyl chloride and the sodium cyanide in a previous video.

( Complete pyrimethamine playlist so far: https://www.youtube.com/playlist?list=PLU79801KtVAU1XsTwHaKkqQoBgz_VYmPS )

Fortunately this is a very mild process and doesn't need exotic conditions like ultraviolet light or high temperatures.

We reflux together 7.2g of potassium iodide, 19g of sodium cyanide, 50g of p-chlorobenzyl chloride and 250mL of dry acetone for at least one full day.

What happens is the iodide replaces the benzylic chloride on the p-chlorobenzyl chloride in a reaction known as the Finkelstein reaction. This highly reactive p-chlorobenzyl iodide now reacts with sodium cyanide to form p-chlorobenzyl cyanide, or p-chlorophenyl acetonitrile.

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https://www.youtube.com/watch?v=15ZkhhJcXXk
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