A group of scientists discover a formula to make animals invisible. Dr. Sebastian Caine, who is in charge of the research, decides to test the serum on himself, but the side effects include personality changes.

Charlie is a socially awkward young man who is always watching life from the sidelines, until two charismatic students become his mentors. Sam and his stepbrother Patrick help Charlie discover the joys of friendship, first love, music and more, while a teacher causes him to dream of being a writer. However, as her new friends prepare to go off to college, her inner sadness threatens to destroy her confidence.