修誦金剛薩埵的淨業法門主要念誦的是百字明咒（藏文：ཡིག་བརྒྱ，威利：yig brgya），祈求金剛薩埵的加持、守護與淨化。 百字明咒的百字即指一百個藏字。

《無垢懺悔續》中說：「百字明是一切善逝的智慧精華，能夠淨除所有的失戒與分別念的罪障，稱為一切懺悔之王。若一次唸誦一百零八遍，則可酬補一切所失之戒，將從三惡趣中獲得解脫。 金剛薩埵在因地時曾發下大願：「願我証得無上佛果時，如果有眾生造五無間罪，破壞三昧耶誓言，一旦他們能聽到我的名號，對我有虔信，念誦咒王百字明，則一切罪障清除無餘，此願不成，我終不証得無上菩提。願我住於破戒者前，他的一切罪障悉皆清凈！」 嗡 邊札薩埵薩瑪雅 瑪奴巴拉雅 邊札薩埵爹奴巴 底他底多美巴哇 蘇埵卡喲美巴哇 蘇波卡喲美巴哇 阿奴啦埵美巴哇 薩哇悉底美札雅札 薩哇嘎瑪蘇札美 茲當悉里養咕嚕吽 哈哈哈哈吽 巴嘎萬 薩哇打他嘎他 邊札瑪美門札 班至巴哇 瑪哈薩瑪雅 薩埵阿

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