Dig into the science of how a single genetic mutation alters the structure of hemoglobin and leads to sickle-cell disease. -- What shape are your cells? Squishy cylinders? Jagged zig-zags? You might not spend a lot of time thinking about the bodies of these building blocks, but microscopically, small variations can have huge consequences. And while some adaptations change these shapes for the better, others can spark debilitating complications. Amber Yates dives into the science of the malignant sickle-cell mutation. Lesson by Amber M. Yates, directed by Axon Animation LLC. Sign up for our newsletter: http://bit.ly/TEDEdNewsletter Support us on Patreon: http://bit.ly/TEDEdPatreon Follow us on Facebook: http://bit.ly/TEDEdFacebook Find us on Twitter: http://bit.ly/TEDEdTwitter Peep us on Instagram: http://bit.ly/TEDEdInstagram View full lesson: https://ed.ted.com/lessons/how-this-disease-changes-the-shape-of-your-cells-amber-m-yates Thank you so much to our patrons for your support! Without you this video would not be possible! Rodrigo Carballo, Boytsov Ilya, EdoKun, Misaki Sato, Craig Sheldon, Andrew Bosco, Catherine Sverko, Nik Maier, Mark Morris, Adi V, Peter Liu, Leora Allen, Hiroshi Uchiyama, Michal Salman, Gilly, Ka-Hei Law, Maya Toll, Ricardo Rendon Cepeda, Renhe Ji, Andrés Melo Gámez, Tim Leistikow, Shawar Khan, Chris, Megan Douglas, Barbara Smalley, Filip Dabrowski, Joe Giamartino, Clair Chen, Vik Nagjee, Karen Goepen-Wee, Della Palacios, Stephanie Perozo, Marc Bilodeau, Ivan Tsenov, Claudia Mayfield, Pavel Zalevskiy, Yankai Liu, Duo Xu, Ghassan Alhazzaa, Miloš Stevanović, Joy Love Om, Gi Nam Lee, Shawn Quichocho, Anika Westburg, Brandy Jones, Devin Harris, Tony Trapuzzano, Jason Weinstein, Kris Siverhus and Alexander Walls.

Dive into the life of Henry Christophe, a former slave and leader in the Haitian Revolution and the only king of Haiti. -- The royal couple of Haiti rode into their coronation to thunderous applause. After receiving his ornate crown, Henry Christophe ascended his throne, towering 20 meters in the air. But little did the cheering onlookers know that the first king of Haiti would also be its last. Who was this revolutionary? Marlene Daut details how a man enslaved at birth rose through the ranks to become king. Lesson by Marlene Daut, directed by Cabong Studios. Animator's website: https://www.cabongstudios.com.br Sign up for our newsletter: http://bit.ly/TEDEdNewsletter Support us on Patreon: http://bit.ly/TEDEdPatreon Follow us on Facebook: http://bit.ly/TEDEdFacebook Find us on Twitter: http://bit.ly/TEDEdTwitter Peep us on Instagram: http://bit.ly/TEDEdInstagram View full lesson: https://ed.ted.com/lessons/the-first-and-last-king-of-haiti-marlene-daut Thank you so much to our patrons for your support! Without you this video would not be possible! Jerome Froelich, Dan Paterniti, Jose Henrique Leopoldo e Silva, Mullaiarasu Sundaramurthy, Elnathan Joshua Bangayan, Caleb ross, Duo Xu, Quinn Shen, Marvin Vizuett, Sid, Marylise CHAUFFETON, Karen Goepen-Wee, Sama aafghani, Mandeep Singh, Abhijit Kiran Valluri, Morgan Williams, Kris Siverhus, Jason Weinstein, Tony Trapuzzano, Devin Harris, Brandy Jones, Shawn Quichocho, Gi Nam Lee, Joy Love Om, Miloš Stevanović, Ghassan Alhazzaa, Yankai Liu, Pavel Zalevskiy, Claudia Mayfield, Stephanie Perozo, Joe Giamartino, Filip Dabrowski, Barbara Smalley, Megan Douglas, Tim Leistikow, Andrés Melo Gámez, Renhe Ji, Ka-Hei Law, Michal Salman, Peter Liu, Mark Morris, Catherine Sverko, Misaki Sato, Tan YH, Ph.D., Rodrigo Carballo, SookKwan Loong, Bev Millar, Merit Gamertsfelder, Lex Azevedo, Noa Shore and Taylor Hunter.