Studies present an association between APOE4 and sleep disturbance. Additionally APOE4 is linked to sleep disturbance before the onset of Alzheimer's symptoms. In ‘The Sleeping Brain’ article (see below) the authors suggest that sleep disturbance causes reduced removal of the waste products from the brain, leading to the accumulation of beta amyloids - which in turn is observed in Alzheimer's disease. Additionally, it is thought that APOE directly leads to beta amyloid metabolism disturbance. And, finally, it is thought that stress-related proteolytic cleavage of APOE4 leads to accumulation of tau proteins. Let's review the evidence. DrBeen: Medical Education Online https://www.drbeen.com/ FLCCC | Front Line COVID-19 Critical Care Alliance https://covid19criticalcare.com/ URL list from Monday, Feb. 20 2023 The Sleeping Brain: Harnessing the Power of the Glymphatic System through Lifestyle Choices - PMC https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698404/ Sleep well — and reduce your risk of dementia and death - Harvard Health https://www.health.harvard.edu/blog/sleep-well-and-reduce-your-risk-of-dementia-and-death-2021050322508 APOE ε4, Alzheimer’s disease neuropathology and sleep disturbance, in individuals with and without dementia | Alzheimer's Research & Therapy | Full Text https://alzres.biomedcentral.com/articles/10.1186/s13195-022-00992-y N3 Phase of Sleep. https://chat.openai.com/chat Understanding Delta Brain Waves And Sleep https://www.sixstepstosleep.com/understanding-delta-brain-waves/ N3: Slow Wave Sleep | Sleepopolis https://sleepopolis.com/education/n3-slow-wave-sleep/ Stage N3 of sleep. Delta waves on EEG recordings are observed.  | Download Scientific Diagram https://www.researchgate.net/figure/Stage-N3-of-sleep-Delta-waves-on-EEG-recordings-are-observed_fig4_280558638 A 30-second Epoch consisting of the parameters of staging sleep... | Download Scientific Diagram https://www.researchgate.net/figure/4-A-30-second-Epoch-consisting-of-the-parameters-of-staging-sleep-electroencephalogram_fig4_282014972 Hallmark of Stage N3 (slow-wave sleep or Stages 3 and 4 sleep: delta... | Download Scientific Diagram https://www.researchgate.net/figure/Hallmark-of-Stage-N3-slow-wave-sleep-or-Stages-3-and-4-sleep-delta-waves_fig1_5812861 Frontiers | Perivascular Spaces, Glymphatic System and MR https://www.frontiersin.org/articles/10.3389/fneur.2022.844938/full Perivascular spaces and brain waste clearance systems: relevance for neurodegenerative and cerebrovascular pathology | SpringerLink https://link.springer.com/article/10.1007/s00234-021-02718-7 Frontiers | Perivascular Unit: This Must Be the Place. The Anatomical Crossroad Between the Immune, Vascular and Nervous System https://www.frontiersin.org/articles/10.3389/fnana.2020.00017/full Neuroglia Lab : Glymphatics and virchow-robin space http://visnu528.blogspot.com/2014/09/glymphatics-and-virchow-robin-space.html Physiology and Clinical Relevance of Enlarged Perivascular Spaces in the Aging Brain | Neurology https://n.neurology.org/content/98/3/107 Aquaporin-4 - Wikipedia https://en.wikipedia.org/wiki/Aquaporin-4 Astrocyte - Wikipedia https://en.wikipedia.org/wiki/Astrocyte Neurocytology-Astrocytes https://neuropathology-web.org/chapter1/chapter1bAstrocytes.html#:~:text=Astrocytic%20foot%20processes%20surround%20brain,maintains%20homeostasis%20in%20the%20CNS. Blood-brain barrier | RIT https://www.rit.edu/spotlights/blood-brain-barrier The Blood-Brain Barrier | Morphology of Nervous System https://sisu.ut.ee/histology/blood-brain-barrier Elimination of substances from the brain parenchyma: efflux via perivascular pathways and via the blood–brain barrier | Fluids and Barriers of the CNS | Full Text https://fluidsbarrierscns.biomedcentral.com/articles/10.1186/s12987-018-0113-6 The glymphatic systems in the brain and the eye export fluid and... | Download Scientific Diagram https://www.researchgate.net/figure/The-glymphatic-systems-in-the-brain-and-the-eye-export-fluid-and-solutes-from_fig1_353240231 External Carotid Artery: Anatomy & Branches | Study.com https://study.com/academy/lesson/external-carotid-artery-anatomy-branches.html Cervical Node Mets fron Occult Primary http://www.aboutcancer.com/cervical_node_occult_utd_907.htm Donate to the Front Line Covid-19 Critical Care Alliance, Inc. https://frontlinecovid-19criticalcarealliance.salsalabs.org/donate/index.html Subscribe to our mailing list on our website:  http://flccc.net/signup Disclaimer: This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only. Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.

Steve Ham was double vaxxed, but chose not to get boosted. A long time follower of the FLCCC, here’s his COVID-19 story. Formed by leading critical care specialists in March 2020, the Front Line COVID-19 Critical Care Alliance (FLCCC) has developed highly effective treatment protocols that aim to prevent and treat COVID-19 at all stages of the disease. We are a 100% donor-supported 501(c)(3) non-profit organization — our work would not be possible without you. Your gifts help us expand our reach and share the latest research available, for the health and well-being of all. If you have a story about your COVID experience we would love to hear it send us a video or an email to mystory@flccc.net. To donate online, click here: https://covid19criticalcare.com/network-support/support-our-work/ To follow FLCCC, click here: https://covid19criticalcare.com/follow-flccc-2/ To learn more about our protocols, click here: https://covid19criticalcare.com/covid-19-protocols/ To register for weekly webinars, click here: https://geni.us/FLCCC_Webinar_Register To buy FLCCC gear, click here: https://supportflccc.store/

Rusty had heard about ivermectin from a documentary cameraman, so when COVID was in the news, he decided to research its effect on COVID and came across The Highwire and the FLCCC. Find out how he used the I-PREVENT and I-CARE protocols with great success in this MyStory. -------------------------------------------- Formed by leading critical care specialists in March 2020, the Front Line COVID-19 Critical Care Alliance (FLCCC) has developed highly effective treatment protocols that aim to prevent and treat COVID-19 at all stages of the disease. We are a 100% donor-supported 501(c)(3) non-profit organization — our work would not be possible without you. Your gifts help us expand our reach and share the latest research available, for the health and well-being of all. If you have a story about your COVID experience we would love to hear it send us a video or an email to mystory@flccc.net. To donate online, click here: https://covid19criticalcare.com/network-support/support-our-work/ To follow FLCCC, click here: https://covid19criticalcare.com/follow-flccc-2/ To learn more about our protocols, click here: https://covid19criticalcare.com/covid-19-protocols/ To register for weekly webinars, click here: https://geni.us/FLCCC_Webinar_Register To buy FLCCC gear, click here: https://supportflccc.store/

Learn how to easily navigate our new FLCCC website’s Provider and Pharmacy directories with our own clinical support specialist, Kristina Morros, CRNA. You can also view related infographic here: https://odysee.com/@FrontlineCovid19CriticalCareAlliance:c/How-to-Navigate-the-New-FLCCC-Website:0 Formed by leading critical care specialists in March 2020, the Front Line COVID-19 Critical Care Alliance (FLCCC) has developed highly effective treatment protocols that aim to prevent and treat COVID-19 at all stages of the disease and treat Post-Vaccine illnesses. Learn more about FLCCC and our protocols here: https://covid19criticalcare.com/ We are a 100% donor-supported 501(c)(3) non-profit organization — our work would not be possible without you. Your gifts help us expand our reach and share the latest research available, for the health and well-being of all. To donate online, click here: https://covid19criticalcare.com/network-support/support-our-work/ To follow FLCCC, click here: https://covid19criticalcare.com/follow-flccc-2/ To learn more about our protocols, click here: https://covid19criticalcare.com/covid-19-protocols/ To register for weekly webinars, click here: https://geni.us/FLCCC_Webinar_Register To buy FLCCC gear, click here: https://supportflccc.store/