A college student named Brandon (Kevin Zegers) collapses after having sex with his fiancée. His symptoms seem too numerous to be explained by just one disease. Foreman and House each suggest different diagnoses and argue that his own respective theory better conforms to Occam's Razor. But then Brandon's white blood cell count drops, proving both doctors wrong. At the clinic pharmacy, House theorizes that the pharmacist accidentally gave Brandon colchicine instead of cough medicine, which explains all of his symptoms aside from his cough. House gives Brandon the cure, and he immediately begins to recover, though nobody believes the pharmacist made a mistake. However, when Brandon comments that his old cough medicine did not have letters on it like his current pills, House discovers colchicine pills that look similar to cough medicine, revealing the source and confirming House's diagnosis.

Dexter removes all of the evidence pointing to his relationship with Vogel before calling the police. Elway and Clayton suspect that Debra is harboring Hannah. Saxon offers Dexter a deal that the two will leave each other alone; Dexter agrees, but secretly plans to kill him before leaving. With a hurricane approaching Miami, Hannah goes to the airport to wait for Dexter, but she is followed by Elway. Meanwhile, Dexter captures Saxon, but realizes that he no longer has murderous urges in response to his relationship with Hannah. Instead of killing Saxon, Dexter calls Debra to arrest him, but Clayton tails Debra and unknowingly interferes. Saxon kills Clayton and escapes after shooting Debra.