Bivalent Booster Efficacy
A study conducted from September 14th to November 11th, 2022 looked at the bivalent booster efficacy. They measured absolute vaccine efficacy (aVE) and relative vaccine efficacy (rVE). Let's review this data.
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
URL list from Monday, Dec. 5 2022
DrBeen: Medical Education Online
https://www.drbeen.com/
Effectiveness of Bivalent mRNA Vaccines in Preventing Symptomatic SARS-CoV-2 Infection — Increasing Community Access to Testing Program, United States, September–November 2022 | MMWR
https://www.cdc.gov/mmwr/volumes/71/wr/mm7148e1.htm
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Random Chit Chat with Dr. Been (#26)
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Vaccine Spike vs. SARS-COV-2 Spike
There has been a lot of discussion for the spike and ACE2 binding. I have recorded many talks on this topic as well. However, an important piece missing for us has been to understand the difference of the spike between the vaccine and the virus. Let's review these differences.
If you like this content and want more, I am doing a special one-time membership offer. Click here: https://www.drbeen.com/yt-special/
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
URL list from Thursday, Nov. 17 2022
DrBeen: Medical Education Online
https://www.drbeen.com/
SARS-CoV-2 spike protein: pathogenesis, vaccines, and potential therapies | SpringerLink
https://link.springer.com/article/10.1007/s15010-021-01677-8
SARS-CoV-2 structural features may explain limited neutralizing-antibody responses | npj Vaccines
https://www.nature.com/articles/s41541-020-00264-6
SARS-CoV-2 spike behavior in situ: a Cryo-EM images for a better understanding of the COVID-19 pandemic | Signal Transduction and Targeted Therapy
https://www.nature.com/articles/s41392-020-00365-7
Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen | PNAS
https://www.pnas.org/doi/10.1073/pnas.1707304114
An mRNA Vaccine against SARS-CoV-2 — Preliminary Report | NEJM
https://www.nejm.org/doi/full/10.1056/NEJMoa2022483
Structure-based design of prefusion-stabilized SARS-CoV-2 spikes - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402631/
SARS-CoV-2 prefusion spike protein stabilized by six rather than two prolines is more potent for inducing antibodies that neutralize viral variants of concern | PNAS
https://www.pnas.org/doi/full/10.1073/pnas.2110105119
Frontiers | Enhancing the Prefusion Conformational Stability of SARS-CoV-2 Spike Protein Through Structure-Guided Design
https://www.frontiersin.org/articles/10.3389/fimmu.2021.660198/full
Closing coronavirus spike glycoproteins by structure-guided design - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302216/
Prefusion Coronavirus Spike Proteins and Their Use | Technology Transfer
https://www.techtransfer.nih.gov/bundle/tab-3261
Locking Down Shape-Shifting Spike Protein Aids Development of COVID-19 Vaccine - UT News
https://news.utexas.edu/2020/08/05/locking-down-shape-shifting-spike-protein-aids-development-of-covid-19-vaccine/
SARS-CoV-2 S protein:ACE2 interaction reveals novel allosteric targets | eLife
https://elifesciences.org/articles/63646
Epitope - Wikipedia
https://en.wikipedia.org/wiki/Epitope
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Dr. Steven Phillips Discusses Dementia and Chronic Diseases
Today we have Dr. Steven Phillips with us to discuss the higher incidence of dementia in individuals with comorbidities in their early part of life.
Dr. Steven Phillips' bio:
Steven Phillips, MD is a well published, Yale-trained physician, researcher, and bestselling author, whose focus of medical practice and research is that chronic and autoimmune illness can be caused by underlying infections.
Want to support this work?:
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
URL list from Thursday, Feb. 3 2022
Is Exposure to BMAA a Risk Factor for Neurodegenerative Diseases? A Response to a Critical Review of the BMAA Hypothesis - PMC
https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7904546/
Number of adults with dementia to exceed 150m by 2050, study finds | Dementia | The Guardian
https://www.theguardian.com/society/2022/jan/06/number-adults-with-dementia-exceed-150-million-2050-study
Two or more chronic health problems in middle age ‘doubles dementia risk’ | Dementia | The Guardian
https://www.theguardian.com/society/2022/feb/02/two-chronic-health-problems-middle-age-double-dementia-risk-multimorbidity-study?CMP=oth_b-aplnews_d-1
Association between age at onset of multimorbidity and incidence of dementia: 30 year follow-up in Whitehall II prospective cohort study | The BMJ
https://www.bmj.com/content/376/bmj-2021-068005#:~:text=Compared%20with%20people%20with%20no,multimorbidity%20was%20at%20age%2070
Chemically induced models of Parkinson's disease - PubMed
https://pubmed.ncbi.nlm.nih.gov/34673252/
Pesticide use in agriculture and Parkinson’s disease in the AGRICAN cohort study | International Journal of Epidemiology | Oxford Academic
https://academic.oup.com/ije/article/47/1/299/4609336?login=false
Amazon.com: Chronic: The Hidden Cause of the Autoimmune Pandemic and How to Get Healthy Again (Audible Audio Edition): Steven Phillips MD, Dana Parish, Teri Schnaubelt, Thomas Allen, Brilliance Audio: Books
https://www.amazon.com/Chronic-Hidden-Autoimmune-Pandemic-Healthy/dp/B0851RT3C6/ref=sr_1_
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This video covers:
Heart as two pumps
Series and parallel circuits
The chemical composition of the venous and arterial blood
Blood flow direction
Various pressures in the CVS
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https://www.youtube.com/watch?v=1TR1aAtTNTw
Pneumoconiosis is non-neoplastic interstitial-fibrosis of the lung due to inhaled mineral dust.
The reaction of the lung to mineral dust depends on many variables, including size, shape, solubility, and reactivity of the particles.
In this video, Dr. Mobeen Syed discusses that the particles greater than 5 to 10 μm are unlikely to reach distal airways.
Particles smaller than 0.5 μm move into and out of alveoli, often without substantial deposition and injury.
Particles that are 1 to 5 μm in diameter are the most dangerous because they get lodged at the bifurcation of the distal airways.
Most inhaled dust trap in the mucus blanket and rapidly remove from the lung by ciliary movement. However, some of the particles become impacted at alveolar duct bifurcations, where macrophages accumulate and engulf the trapped particulates.
The pulmonary alveolar macrophage is an essential cellular element in the initiation and perpetuation of lung injury and fibrosis.
Particles trigger the macrophages to release several products that mediate an inflammatory response and initiate fibroblast proliferation and collagen deposition.
Some of the inhaled particles may reach the lymphatics either by direct drainage or within migrating macrophages and thereby initiate an immune response.
In this way, inflammation and fibrosis occur both in the lung parenchyma and lymphatics.
The following topics have discussed in the video:
* Pneumoconiosis
* Role of the size of dust particles in pneumoconiosis
* Mechanism of the pathogenesis of pneumoconiosis
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https://www.youtube.com/watch?v=i3XO2NZsE-M
Glenmark's FabiFlu approved for coronavirus treatment in India, costs Rs 103 per tablet
Mumbai-based Glenmark Pharmaceuticals have launched a new antiviral drug - Favipiravir with brand name FabiFlu - for the treatment of mild to moderate Covid-19 patients. The firm has become the first Indian company to commercially launch the antiviral drug.
https://www.indiatoday.in/india/story/coronavirus-treatment-drug-glenmark-fabiflu-favipiravir-launch-india-rs-103-per-tablet-reduce-viral-load-1691066-2020-06-20
Coronavirus replication
https://www.ncbi.nlm.nih.gov/books/NBK554776/figure/article-52171.image.f1/
RdRp is the main enzyme of transcription-replication complex
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2322833/
Favipiravir mechanism of action and its study
https://www.biorxiv.org/content/10.1101/2020.05.15.098731v1.full.pdf+html
Experimental Treatment with Favipiravir for COVID-19: An Open-Label Control Study
https://www.sciencedirect.com/science/article/pii/S2095809920300631?via%3Dihub
Potential coronavirus drug approved for marketing
Favipiravir, an antiviral that has shown potential in treating the novel coronavirus, was approved for marketing, the Taizhou government of Zhejiang province announced Sunday.
https://www.chinadaily.com.cn/a/202002/17/WS5e49efc2a310128217277fa3.html
Therapeutic options for the 2019 novel coronavirus (2019-nCoV)
Therapeutic options in response to the 2019-nCoV outbreak are urgently needed. Here, we discuss the potential for repurposing existing antiviral agents to treat 2019-nCoV infection (now known as COVID-19), some of which are already moving into clinical trials.
https://www.nature.com/articles/d41573-020-00016-0
Fujifilm Announces the Start of a Phase III Clinical Trial of Influenza Antiviral Drug Avigan (favipiravir) on COVID-19 in Japan and Commits to Increasing Production
https://www.drugs.com/clinical_trials/fujifilm-announces-start-phase-iii-clinical-trial-influenza-antiviral-avigan-favipiravir-covid-19-18505.html
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https://www.youtube.com/watch?v=WQe0cm1Ma3A
5-15 Minutes COVID-19 Test At Home - Dr. Bobby Brooke Herrera Discusses Rapid Testing Kits From His Company
E25Bio Inc., has developed a rapid home based and point-of-care (POC) testing kit for COVID-19. They are developing such kits for other viruses as well. We are excited to have the Co-Founder and the CEO of E25Bio with us today.
On their website the team says, “We've managed to develop an investigational SARS and SARS-CoV-2 rapid tests in 3 weeks.”
About E25Bio
https://e25bio.com/about/
E25Bio revolves around an idea that technology that saves lives is in fact simple.
Our goal is to predict outbreaks around the world and help control them using unique and affordable testing solutions.
Twitter for E25Bio Inc
https://twitter.com/E25Bio
Dr. Bobby Brooke Herrera’s Profile
https://e25bio.com/bobby-brooke-herrera/
Herrera is Forbes’ 30 under 30
https://www.forbes.com/30-under-30/2020/healthcare/#29accf997f75
Products by E25Bio
https://e25bio.com/products/
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