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This video presents the following topics about primary tuberculosis: Epidemiology Etiology Pathogenesis Primary Tuberculosis Morphology Clinical Aspects ... https://www.youtube.com/watch?v=WzPnrPt2qAM
Factors associated with psychiatric outcomes and coping in Long COVID
Let's review the first ever study about the factors associated with psychiatric outcomes in long COVID.
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
URL list from Friday, Jun. 12 2023
Factors associated with psychiatric outcomes and coping in Long COVID | Nature Mental Health
https://www.nature.com/articles/s44220-023-00064-6
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https://www.youtube.com/watch?v=3CDZOsyUqb0
Omicron - Questions with Dr. Been (#158)
Let's have fun and talk :-)
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
...
https://www.youtube.com/watch?v=-AlOS8rt7gs
Unvaccinated and Omicron - Study from California (Preprint)
A study sponsored by CDC shows that Omicron is less severe in vaccinated and unvaccinated patients. Let's review how less?
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Reference URL list from Wednesday, Jan. 12 2022
California Hospitals Find Omicron Causes Fewer Hospitalizations, Shorter Stays - The New York Times
https://www.nytimes.com/2022/01/11/health/california-omicron-hospitalizations.html
Clinical outcomes among patients infected with Omicron (B.1.1.529) SARS-CoV-2 variant in southern California | medRxiv
https://www.medrxiv.org/content/10.1101/2022.01.11.22269045v1
Clinical outcomes among patients infected with Omicron (B.1.1.529) SARS-CoV-2 variant in southern California
https://www.medrxiv.org/content/10.1101/2022.01.11.22269045v1.full.pdf
Gupta labs: https://medicine.yale.edu/childstudy/research/basic/neurogen/guptalab/
HKUMed study: https://www.med.hku.hk/en/news/press/20211215-omicron-sars-cov-2-infection
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
...
https://www.youtube.com/watch?v=D0gWB9M8538
Europe, Asia, Africa, ME - COVID Questions with Dr. Been (#14)
Let’s discuss the possible answers to your questions about COVID
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https://news.yahoo.com/official-chinese-vaccines-effectiveness-low-053640063.html
How India lost the vaccine war - The Ken
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https://www.youtube.com/watch?v=aW-F8NzwEjs
Preprint: Effectiveness of the Coronavirus Disease 2019 (COVID-19) Bivalent Vaccine
The purpose of this study was to evaluate whether the bivalent COVID-19 vaccine protects against COVID-19.
Study does show that the increased number of doses were associated with a small but statistically significant increase risk of infection.
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
Flaws of this study:
Retrospective, cohort, study. Not
For me the study stops being usefule at the counting of cases instead of counting moderate to severe cases.
If the immune system was weakened then the participants should have more severe form of infection after each shot (not just more cases). But the study says: "There were too few severe illnesses for the study to be able to determine if the vaccine decreased severity of illness."
Days
Also counting a case without regard to the window of adaptive arm activation isn't correct. For example 14 days from the vaccination. The bivalent vaccine was considered vaccinated based on 7 days after the vaccination - which seems OK to me.
Antibodies for sure wane. So, will cases occur, yes they will. Question is severe cases.
Every new dose will wane away. The only protection to test for is the severe cases. They admit that there were not many severe cases. I would have loved to see whatever number they had. It will be more clarifying than the cases. Also, the time since the vaccination (regardless of the number of doses) matters, not the number of doses.
Exposure types of the partcipants in the clinical settings will matter a lot for the outcomes. They have 50.6% clinical and 49.4% non-clinical cohort. They could only show the difference between these two but stated that they could not go deeper in the data due to the institutional limitations.
URL list from Tuesday, Jan. 10 2023
Effectiveness of the Coronavirus Disease 2019 (COVID-19) Bivalent Vaccine | medRxiv
https://www.medrxiv.org/content/10.1101/2022.12.17.22283625v1.full
Class switch towards non-inflammatory, spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination | Science Immunology
https://www.science.org/doi/10.1126/sciimmunol.ade2798
Circulating Spike Protein Detected in Post–COVID-19 mRNA Vaccine Myocarditis | Circulation
https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.122.061025
COVID vaccine study raises questions about boosters | Sandusky Register Vaccines save lives, but multiple boosters for COVID may not help, study suggests
https://sanduskyregister.com/news/436005/covid-vaccine-study-raises-questions-about-boosters/
COVID-19 Vaccine FAQs | Cleveland Clinic
https://my.clevelandclinic.org/landing/covid-19-vaccine
Estimated SARS-CoV-2 antibody seroprevalence trends and relationship to reported case prevalence from a repeated, cross-sectional study in the 50 states and the District of Columbia, United States—October 25, 2020–February 26, 2022 - The Lancet Regional Health – Americas
https://www.thelancet.com/journals/lanam/article/PIIS2667-193X(22)00220-4/fulltext
Coronavirus (COVID-19) latest insights - Office for National Statistics
https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/articles/coronaviruscovid19latestinsights/antibodies
SARS-CoV-2 Serology and Self-Reported Infection Among Adults — National Health and Nutrition Examination Survey, United States, August 2021–May 2022 | MMWR
https://www.cdc.gov/mmwr/volumes/71/wr/mm7148a4.htm
Frontiers | SARS-CoV-2 infections among asymptomatic individuals contributed to COVID-19 cases: A cross-sectional study among prospective air travelers from Ghana
https://www.frontiersin.org/articles/10.3389/fpubh.2022.1035763/full
Percentage of Asymptomatic Infections among SARS-CoV-2 Omicron Variant-Positive Individuals: A Systematic Review and Meta-Analysis - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9321237/
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https://www.youtube.com/watch?v=prPzMfYEaWo
Open Forum September 4th 2020
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Link to the Twitter thread: https://twitter.com/drbeen_medical/status/1300981286245343232?s=21
Picture:
Frank and Marita are caring for these two little rascals :-)
For the supplements question. Wanted to share how Mayo Clinic positions themselves about the supplements:
https://www.mayoclinic.org/diseases-conditions/coronavirus/in-depth/coronavirus-myths/art-20485720
Can the virus spread through the sweat glands
https://www.hopkinsmedicine.org/health/conditions-and-diseases/coronavirus/coronavirus-frequently-asked-questions
Can ACE Inhibitors increase the risk of COVID?
https://heart.bmj.com/content/early/2020/08/13/heartjnl-2020-317393
Can the virus spread through fecal aerosol in large buildings?
https://www.acpjournals.org/doi/10.7326/M20-0928
Fecal aerosol transmission
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7166010/
Can Apple Cider Vinegar reduce renin levels?
https://medicompinc.com/new-miracle-medicine-apple-cider-vinegar/#:~:text=Acetic%20acid%20is%20the%20main,for%20increasing%20your%20blood%20pressure.
https://pubmed.ncbi.nlm.nih.gov/11826965/
What is the actual infection rate from COVID-19?
https://www.timesnownews.com/delhi/article/delhi-congested-areas-have-highest-covid-19-infection-rate-serological-surveillance-tests-indicate/626104
Sweden is a good case to try to find the infection rate
https://www.medpagetoday.com/infectiousdisease/covid19/87812
Let’s look in Sweden
https://camera.deckchair.com/sheraton-stockholm-sweden
Swedes are not wearing masks
https://unherd.com/2020/07/swedens-anders-tegnell-judge-me-in-a-year/
Sweden death rate is dropping
https://www.worldometers.info/coronavirus/country/sweden/
Sweden population by age
https://www.indexmundi.com/sweden/age_structure.html
Sweden coronavirus deaths by age
https://www.statista.com/statistics/1107913/number-of-coronavirus-deaths-in-sweden-by-age-groups/
Sweden cases by age
https://www.statista.com/statistics/1107905/number-of-coronavirus-cases-in-sweden-by-age-groups/
HIV and COVID
https://www.avert.org/coronavirus/covid19-HIV
How long can a person shed from nasopharyngeal tract after the symptoms resolve?
https://www.health.harvard.edu/diseases-and-conditions/if-youve-been-exposed-to-the-coronavirus#:~:text=Most%20people%20with%20coronavirus%20who,there%20are%20documented%20exceptions.
My questions for Fauci
Why are you not focusing on ways to aggressively managing the virus in the early phase?
Why is there no prophylactic protocol adopted so far? May be look towards India for help.
Have you collected data from outpatient doctors to understand the management methods for outpatient?
Have your orga
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https://www.youtube.com/watch?v=MuRk3jaiTBg
What Are Cancers? Cancer Immunology (Part 2) with Prof. Dr. William Murphy
Dr. William J. Murphy is a scientist with extensive experience with immune and the cancer system interactions. Dr. Murphy has graciously offered to help us understand cancer immunology.
Today we will focus more on the CAR-T therapy.
Brief bio of Dr. Murphy:
My research for the past 30 years has centered on translational studies involving modeling cancer-immune system interactions starting with my earlier studies on NK cells and HSCT in mouse models and later at the National Cancer Institute on their role in cancer immunotherapy which then expanded to issues in immunotherapy in general.
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Buy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
References with some previous talks
COVID Research - A Talk With Dr. William J. Murphy - YouTube
https://www.youtube.com/watch?v=UdmaZX3ftfY
Dr. William J. Murphy, Ph.D. for UC Davis Health
https://health.ucdavis.edu/team/search/1226/william-murphy---cancer---dermatology---hematology-oncology---pathology---dermatopathology-sacramento
A Possible Role for Anti-idiotype Antibodies in SARS-CoV-2 Infection and Vaccination | NEJM
https://www.nejm.org/doi/full/10.1056/NEJMcibr2113694
Autoimmune Disease after Infection or Vaccine in Some (Article Review of Anti-idiotype Antibodies) - YouTube
https://www.youtube.com/watch?v=kE9UUX7NV5Q
...
https://www.youtube.com/watch?v=YgrY5avVA64
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From Wikipedia:
https://en.wikipedia.org/wiki/Lenzilumab
Lenzilumab (INN; development code KB003)[1] is a humanized monoclonal antibody (class IgG1 kappa)[2] that targets colony stimulating factor 2 (CSF2)/granulocyte-macrophage colony stimulating factor (GM-CSF).
First Clinical Use of Lenzilumab to Neutralize GM-CSF in Patients with Severe COVID-19 Pneumonia
https://www.medrxiv.org/content/10.1101/2020.06.08.20125369v2
Humanigen reports positive results from lenzilumab Covid-19 study
https://www.clinicaltrialsarena.com/news/humanigen-lenzilumab-covid-19-patients/
Case report: use of lenzilumab and tocilizumab for the treatment of coronavirus disease 2019
https://www.futuremedicine.com/doi/10.2217/imt-2020-0136
Interleukin 6
https://en.wikipedia.org/wiki/Interleukin_6
GM-CSF
https://en.wikipedia.org/wiki/Granulocyte-macrophage_colony-stimulating_factor
...
https://www.youtube.com/watch?v=g8LFxGh2u28
Bamlanivimab FDA EUA for COVID
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Bamlanivimab is a recombinant antibody by Lilly.
Bamlanivimab is approved for non-hospitalized, non oxygen requiring, non ventilated patients of mild to moderate COVID-19 that are deemed high risk of severe disease.
Criteria for high risk patients
https://www.covid19treatmentguidelines.nih.gov/statement-on-bamlanivimab-eua
DrBeen’s discussion of how monoclonal antibodies are made?
https://youtu.be/Y-qNdFMRiis
DrBeen’s explanation of the recombinant technology
https://youtu.be/Y-qNdFMRiis?t=2339
What are recombinant monoclonal antibodies?
Complete Guide to Recombinant Antibodies | Benefits & Uses
Bamlanivimab mechanism of action
Lilly's neutralizing antibody bamlanivimab (LY-CoV555) receives FDA emergency use authorization for the treatment of recently diagnosed COVID-19 | Eli Lilly and Company
FDA EUA granted An EUA for Bamlanivimab—A Monoclonal Antibody for COVID-19 | Infectious Diseases | JAMA | JAMA Network
Bamlanivimab clinical trial
Bamlanivimab (LY-Cov555) for the Treatment of COVID-19, USA
#drbeen #koolbeens #COVID
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https://www.youtube.com/watch?v=YO6HJfiCVU0