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Vaccine Spike vs. SARS-COV-2 Spike - Part 2
Vaccine Spike vs. SARS-COV-2 Spike - Part 2
In this part 2 we will discuss the long COVID like pathogenesis from vaccines and the potential etiology while the spike is locked in prefusion (S-2P) state.
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
URL list from Sunday, Nov. 20 2022
RBD does not bind in the down position.
Frontiers | Epitope Classification and RBD Binding Properties of Neutralizing Antibodies Against SARS-CoV-2 Variants of Concern
https://www.frontiersin.org/articles/10.3389/fimmu.2021.691715/full
Excerpt:
To date, NAbs targeting SARS-CoV-2 RBD have been classified into four structural groups, C1-C4 (Figure 1), based on their ability to bind to up or down conformations of the SARS-CoV-2 RBD, and by their overlap with the ACE2 binding site (17). The C1 class is defined by NAbs that bind within the RBD ACE2 binding site, essentially mimicking ACE2 binding, and thus only bind to RBD when it is in the up conformation. The C1 class contains conserved ACE2-blocking NAbs, often composed of heavy chains encoded by the VH3-52 and VH3-66 gene segments (25). C2 NAbs block the ACE2 binding site yet can bind to RBD in its up and down conformations. C3 NAbs bind largely outside the ACE2 binding site of RBD in both up and down conformations, while a fourth class (C4) binds farther from the ACE2 binding site and the epitope is only accessible once SARS-CoV-2 S undergoes large conformational changes (30). Overall, a variety of NAb/RBD structures have been completed and their interactions defined (see refs. in Table 1).
Viral targets for vaccines against COVID-19 | Nature Reviews Immunology
https://www.nature.com/articles/s41577-020-00480-0
fimmu-12-691715-g001.jpg (1242×734)
https://www.frontiersin.org/files/Articles/691715/fimmu-12-691715-HTML-r1/image_m/fimmu-12-691715-g001.jpg
mRNA vaccine-induced antibodies more effective than natural immunity in neutralizing SARS-CoV-2 and its high affinity variants | Scientific Reports
https://www.nature.com/articles/s41598-022-06629-2
Vaccines | Free Full-Text | Variation in the Humoral Immune Response Induced by the Administration of the BNT162b2 Pfizer/BioNTech Vaccine: A Systematic Review
https://www.mdpi.com/2076-393X/10/6/909/htm
Structure-based Design of Prefusion-stabilized SARS-CoV-2 Spikes - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302215/
Adjuvanted SARS-CoV-2 spike protein elicits neutralizing antibodies and CD4 T cell responses after a single immunization in mice - eBioMedicine
https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(20)30573-9/fulltext
Frontiers | Epitope Classification and RBD Binding Properties of Neutralizing Antibodies Against SARS-CoV-2 Variants of Concern
https://www.frontiersin.org/articles/10.3389/fimmu.2021.691715/full
A Possible Role for Anti-idiotype Antibodies in SARS-CoV-2 Infection and Vaccination | NEJM
https://www.nejm.org/doi/10.1056/NEJMcibr2113694
Anti-idiotype Antibodies in SARS-CoV-2 Infection and Vaccination | NEJM
https://www.nejm.org/doi/full/10.1056/NEJMc2119443
SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans | Nature
https://www.nature.com/articles/s41586-021-03647-4
COVID‐19 and plasma cells: Is there long‐lived protection?* - Nguyen - 2022 - Immunological Reviews - Wiley Online Library
https://onlinelibrary.wiley.com/doi/full/10.1111/imr.13115
...
https://www.youtube.com/watch?v=pgChem4xeAI
In this part 2 we will discuss the long COVID like pathogenesis from vaccines and the potential etiology while the spike is locked in prefusion (S-2P) state.
If you like this content and want more, I am doing a special one-time membership offer. Click here: https://www.drbeen.com/yt-special/
Want to support this work?:
Buy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed
Become my patron: https://www.patreon.com/mobeensyed?fan_landing=true
PayPal: https://paypal.me/mobeensyed?locale.x=en_US
My substack: https://mobeensyedmd.substack.com/
#drbeen #koolbeens #COVID
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
URL list from Sunday, Nov. 20 2022
RBD does not bind in the down position.
Frontiers | Epitope Classification and RBD Binding Properties of Neutralizing Antibodies Against SARS-CoV-2 Variants of Concern
https://www.frontiersin.org/articles/10.3389/fimmu.2021.691715/full
Excerpt:
To date, NAbs targeting SARS-CoV-2 RBD have been classified into four structural groups, C1-C4 (Figure 1), based on their ability to bind to up or down conformations of the SARS-CoV-2 RBD, and by their overlap with the ACE2 binding site (17). The C1 class is defined by NAbs that bind within the RBD ACE2 binding site, essentially mimicking ACE2 binding, and thus only bind to RBD when it is in the up conformation. The C1 class contains conserved ACE2-blocking NAbs, often composed of heavy chains encoded by the VH3-52 and VH3-66 gene segments (25). C2 NAbs block the ACE2 binding site yet can bind to RBD in its up and down conformations. C3 NAbs bind largely outside the ACE2 binding site of RBD in both up and down conformations, while a fourth class (C4) binds farther from the ACE2 binding site and the epitope is only accessible once SARS-CoV-2 S undergoes large conformational changes (30). Overall, a variety of NAb/RBD structures have been completed and their interactions defined (see refs. in Table 1).
Viral targets for vaccines against COVID-19 | Nature Reviews Immunology
https://www.nature.com/articles/s41577-020-00480-0
fimmu-12-691715-g001.jpg (1242×734)
https://www.frontiersin.org/files/Articles/691715/fimmu-12-691715-HTML-r1/image_m/fimmu-12-691715-g001.jpg
mRNA vaccine-induced antibodies more effective than natural immunity in neutralizing SARS-CoV-2 and its high affinity variants | Scientific Reports
https://www.nature.com/articles/s41598-022-06629-2
Vaccines | Free Full-Text | Variation in the Humoral Immune Response Induced by the Administration of the BNT162b2 Pfizer/BioNTech Vaccine: A Systematic Review
https://www.mdpi.com/2076-393X/10/6/909/htm
Structure-based Design of Prefusion-stabilized SARS-CoV-2 Spikes - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302215/
Adjuvanted SARS-CoV-2 spike protein elicits neutralizing antibodies and CD4 T cell responses after a single immunization in mice - eBioMedicine
https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(20)30573-9/fulltext
Frontiers | Epitope Classification and RBD Binding Properties of Neutralizing Antibodies Against SARS-CoV-2 Variants of Concern
https://www.frontiersin.org/articles/10.3389/fimmu.2021.691715/full
A Possible Role for Anti-idiotype Antibodies in SARS-CoV-2 Infection and Vaccination | NEJM
https://www.nejm.org/doi/10.1056/NEJMcibr2113694
Anti-idiotype Antibodies in SARS-CoV-2 Infection and Vaccination | NEJM
https://www.nejm.org/doi/full/10.1056/NEJMc2119443
SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans | Nature
https://www.nature.com/articles/s41586-021-03647-4
COVID‐19 and plasma cells: Is there long‐lived protection?* - Nguyen - 2022 - Immunological Reviews - Wiley Online Library
https://onlinelibrary.wiley.com/doi/full/10.1111/imr.13115
...
https://www.youtube.com/watch?v=pgChem4xeAI
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This video is part of a series of topics about right heart failure. Dr. Mobeen discusses the following topics:
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Positive PCR Test. Is It Really Positive?
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Today we will discuss the CDC recommendation for the utility of the PCR tests. We will also discuss the recommendations by the epidemiologists. And, finally I will provide my commentary.
CDCs Thoughts on PCR
https://www.cdc.gov/coronavirus/2019-ncov/hcp/duration-isolation.html
Impacts contact tracing.
Begs the question; if someone had coronavirus fragments. Did he/she develop the immunity? That means, before blindly reducing the cycle threshold. We should have done a trial of testing for PCR with Antibodies at both cycle thresholds.
Your Coronavirus Test Is Positive. Maybe It Shouldn’t Be.
https://www.nytimes.com/2020/08/29/health/coronavirus-testing.html
CDCs Clarification
https://www.nytimes.com/2020/08/27/us/politics/trump-coronavirus-testing.html
Faster tests are better
https://www.nytimes.com/2020/08/06/health/rapid-Covid-tests.html
A possible fast test
https://e25bio.com/bobby-brooke-herrera/
CDC article about PCR
https://wwwnc.cdc.gov/eid/article/26/8/20-1246_article
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CDC Kentucky Study - Reduced Risk Of Reinfection with Vaccines Compared To Natural Infection
CDC has posted a retrospective study that observed the reinfection in previously infected and then vaccinated vs. previously infected and not vaccinated individuals. According to the authors the likelihood of a reinfection is 2.3 times if you are infected and not vaccinated. Let's review the study.
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References
DrBeen Site: drbeen.com
CDC site page with the study: https://www.cdc.gov/mmwr/volumes/70/wr/mm7032e1.htm
PDF for the study: https://www.cdc.gov/mmwr/volumes/70/wr/pdfs/mm7032e1-H.pdf
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Vero cell line (for virus culture)
https://en.wikipedia.org/wiki/Vero_cell
Beta-propiolactone (for inactivating the virus)
https://en.wikipedia.org/wiki/Beta-Propiolactone
How is the COVAXIN like vaccines made?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202686/
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https://www.firstpost.com/india/bharat-biotech-icmr-publish-covaxin-phase-1-2-safety-data-in-an-interim-report-in-lancet-9229311.html
Press Information Bureau Government of India
https://pib.gov.in/PressReleseDetail.aspx?PRID=1685761
Regulatory approval of COVID-19 vaccine for restricted use in clinical trial mode
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(21)00045-1/fulltext
India begins COVID-19 vaccination amid trial allegations
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)00145-8/fulltext
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https://thewire.in/health/mitali-mukherjee-ashish-jha-bharat-biotech-covaxin
Scientists Urge Govt to Release Covaxin Phase 3 Trial Data Before Rollout
https://science.thewire.in/health/bharat-biotech-covaxin-vaccine-data/
How COVAXIN works?
https://www.nytimes.com/interactive/2021/health/bharat-biotech-covid-19-vaccine.html
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Amazon.com: Chronic: The Hidden Cause of the Autoimmune Pandemic and How to Get Healthy Again (Audible Audio Edition): Steven Phillips MD, Dana Parish, Teri Schnaubelt, Thomas Allen, Brilliance Audio: Books
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Disclaimer:
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Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
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Study pre-print
https://www.medrxiv.org/content/10.1101/2021.01.11.20248765v2
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