This video is a brief overview of the current state of information on marijuana and its two major cannabinoids - cannabidiol (CBD) and tetrahydrocannabinol (THC) - and their potential uses in head and neck cancer treatment.
Epidemiology
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947141/
https://pubmed.ncbi.nlm.nih.gov/30466476/
In vitro and in vivo lab data
https://www.nature.com/articles/s41598-020-77674-y
https://clincancerres.aacrjournals.org/content/26/11/2693
Anxiety, depression, and fatigue in head and neck cancer patients
https://pubmed.ncbi.nlm.nih.gov/18513884/
https://pubmed.ncbi.nlm.nih.gov/23239423/
https://pubmed.ncbi.nlm.nih.gov/17398020/
Marijuana as a complementary treatment
https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/2688527
https://pubmed.ncbi.nlm.nih.gov/27005465/
Xerostomia and salivary flow
https://pubmed.ncbi.nlm.nih.gov/16946411/
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https://www.youtube.com/watch?v=m77MpwLlcCw
Really nice presentation at the ACIP meeting today about the variants of concern (P1 B.1.351 B.1.1.7) in the US and the effectiveness of the vaccines against the variants and what this probably means for us.
https://www.cdc.gov/vaccines/acip/meetings/downloads/slides-2021-05-12/10-COVID-Scobie-508.pdf
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https://www.youtube.com/watch?v=SwcdYc7xg4M
In this video we go over what molnupiravir is, how it works, and what the potential for DNA damage and mutations are.
https://www.nature.com/articles/s41594-021-00657-8
https://www.virology.ws/2021/10/14/molnupiravir-the-sars-cov-2-antiviral-is-mutagenic-for-cells/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8136050/
https://www.science.org/content/blog-post/molnupiravir-mutations
https://www.merck.com/news/merck-and-ridgebacks-investigational-oral-antiviral-molnupiravir-reduced-the-risk-of-hospitalization-or-death-by-approximately-50-percent-compared-to-placebo-for-patients-with-mild-or-moderat/
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https://www.youtube.com/watch?v=j3q2ECBWWIM
I decided to find out what the deal with the new variant of SARS-CoV2 ( B.1.1.7 ) is. We know a lot of the structure and very little about the consequences of the structural changes right now.
Papers and sites used.
https://www.gisaid.org
https://users.math.msu.edu/users/weig/SARS-CoV-2_Mutation_Tracker.html
https://khub.net/documents/135939561/338928724/SARS-CoV-2+variant+under+investigation%2C+meeting+minutes.pdf/962e866b-161f-2fd5-1030-32b6ab467896?t=1608470511452
https://virological.org/t/preliminary-genomic-characterisation-of-an-emergent-sars-cov-2-lineage-in-the-uk-defined-by-a-novel-set-of-spike-mutations/563
https://www.ecdc.europa.eu/sites/default/files/documents/SARS-CoV-2-variant-multiple-spike-protein-mutations-United-Kingdom.pdf
https://www.nature.com/articles/s41401-020-0485-4
https://www.cogconsortium.uk/wp-content/uploads/2020/12/Report-1_COG-UK_20-December-2020_SARS-CoV-2-Mutations_final.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196923/
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https://www.youtube.com/watch?v=9MCYZkicjgA
A really important question is what percentage of covid infections are asymptomatic. It seems we have a pretty good answer at this point.
Video about the SIREN study
https://www.youtube.com/watch?v=F-DVjdfpYiM
Links
https://www.acpjournals.org/doi/10.7326/M20-6976
https://www.medrxiv.org/content/10.1101/2021.01.13.21249642v1.full
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https://www.youtube.com/watch?v=u1lTsJD8jKg
These graphs from the UK are encouraging and seem to indicate that the current Delta variant surge won't lead to as many deaths as previous surges.
https://www.worldometers.info/coronavirus/country/uk/
https://www.worldometers.info/coronavirus/country/us/
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https://www.youtube.com/watch?v=ewDz37ZXV48
As expected, it's already here and it's been here for a while. This highlights the difficulty in managing a disease with a presymptomatic/asymptomatic but infectious stage.
https://www.cdc.gov/media/releases/2021/s1201-omicron-variant.html
https://www.krisp.org.za/manuscripts/25Nov2021_B.1.1.529_Media.pdf
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https://www.youtube.com/watch?v=5hWO3AkE4cM
Maybe gut microbiome transplants will be a treatment for diabetes in the future.
https://www.sciencedirect.com/science/article/pii/S001650851200892X
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https://www.youtube.com/watch?v=NbdIBFaGPqk
Finally we have some actual data.
https://www.medrxiv.org/content/10.1101/2021.12.07.21267432v2
https://drive.google.com/file/d/1CuxmNYj5cpIuxWXhjjVmuDqntxXwlfXQ/view
https://www.ahri.org/wp-content/uploads/2021/12/MEDRXIV-2021-267417v1-Sigal.pdf
https://investors.biontech.de/news-releases/news-release-details/pfizer-and-biontech-provide-update-omicron-variant
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https://www.youtube.com/watch?v=GHYHfbxzQAo