Understanding Alzheimer's Disease and the Precursors for Dementia - An In-Depth Discussion with...
How does the aging process lead to neurodegenerative diseases? Research shows that neuroinflammation may play a key role. Press play to learn:
What a Tau protein is and how it plays a role in Alzheimer's disease How Alzheimer's disease is diagnosed How amyloid plaques alter your brain Professor of neuroscience and anatomy Gorin Šimić joins the conversation to discuss Alzheimer's disease and Dementia.
Research shows that amyloid present in the brain for a short time can be beneficial, but if present for too long, can cause neurodegeneration. This has been discovered through a shift in the understanding of Dementia and has re-worked the criteria for diagnosis.
Since Alzheimer's disease cannot be solved by evolution or natural selection, lifestyle can play a role until a certain age. However, past a certain point, genetic factors are the key in determining the onset of neurodegenerative diseases.
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Have you ever tried to store rainwater only to find it fouled and unusable? ?
John Hancock, who has committed his time and energy to educating people about the sustainable benefits that off-grid living practices can offer, offers a
few tips to help you store water in a more sustainable way.
According to John there are TWO practical ways you can prevent your stored water from getting fouled. ?
He shares that the most important step anyone looking to store water for some time need to do is to install a wire mesh over their gutters and to invest in a good filter with different substrates to filter out any impurities that may cause biofilm or algae to develop in the stored water. ?
What are your thoughts about John’s advice on how to store water? Let us know in the comments!
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https://www.youtube.com/watch?v=1WB0bTi6TXc
What does it mean to treat the patient, not the disease? Dr. Gary Foresman helps listeners understand what this looks like in a day-to-day approach to cancer therapies, from new cancer treatments to integrative oncology. Listen and learn
Why he seeks a middle approach between western and eastern medicine, harnessing the best of what each has to offer, How he understands true integrative medicine as that which centers the patient not theories, and What daily habits can help healing through any cancer staging and how he brings patients through the process. Dr. Gary Foresman specializes in integrative cancer therapies and regenerative medicine. He's the founder of Middle Path Medicine and works entirely in the clinical field. He's able to paint a very clear picture for listeners of what it could mean to approach cancer treatment through an integrative path. This makes for a patient-oriented habit of practice, he explains. Each person makes their choice—sometimes that means more of a western approach with targeted chemo, and sometimes this means more of a natural approach. This patient-centered treatment, he adds, is really what integrative medicine should be. Ultimately, integrative practitioners are "providing tools for patients and allowing them to make better, informed decisions."
This means he takes a slightly different approach to counseling patients through diet and exercise choices and even meditation as ways to treat cancer. But, he's clear that nutrition treats people and not diseases: rather than ask which diet is best for cancer or heart disease, one should ask which diet is best for themselves, he explains. Often the first thing he talks about with a patient is their stress levels, an extremely important element in cancer treatment and healing. Therefore, he's sensitive to pushing them towards diets or changes that might engender more stress rather than increase health outcomes. But he's honest with patients about what food, exercise, and mindful practices could provide them with a healthful balance alongside western approaches to treatment. Listen in to hear more about what forms this advice takes.
For more about Dr. Gary Foresman, see Middle Path Medicine. Episode also available on Apple Podcasts: apple.co/30PvU9C
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https://www.youtube.com/watch?v=jekyvRRLRwA
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Dr. Theodore Belfor, dental innovator and expert, discusses a wide variety of dental issues with a special emphasis on airway issues, snoring causes and effect, as well as snoring treatment. Dr. Belfor graduated from the New York University School of Medicine. He works in Catskill, NY and specializes in General Dentistry.
Dr. Belfor discusses airway issues, daytime and nighttime, from stuffy noses to more serious airway problems. As Dr. Belfor states, chronic rhinosinusitis is an extremely common problem. This persistent, nagging health issue is defined by the presence of at least two of four major symptoms, such as facial pain and/or pressure, hyposmia/anosmia, nasal drainage, and sometimes nasal obstruction, for at minimum—12 consecutive weeks.
He explains how the cilia (tiny hairs in our noses) along with mucus, trap the bacteria. But when our sinuses are working properly, these bacteria can be neutralized in most cases. However, when chronic rhinosinusitis occurs, there is a sort of broken link in this chain of defense, and the body will go into its normal defenses, which equates to swelling and inflammation. Dr. Belfor explains the function of nitric oxide, and the jaw, and how the system can become overextended, enabling polyp growth possibilities and more.
Dr. Belfor discusses misalignment, airway and snoring issues, etc. including information on breathing systems. Further, he explains the many possibilities for care and treatment, often without surgical procedures.
He talks about the ways to ‘turn the genes on’ to get the body to respond, and improve functioning. He expounds upon the processes of ‘toning the airway’ as well as the difficult problems posed by snoring and sleep apnea. Continuing, the airway expert talks in detail about anatomy, and the physical components that contribute to dental and airway issues.
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In this podcast:
1. What are the main contributors to airway breathing issues?
2. How to ‘turn genes on’ to get the body to respond to issues
3. How does a nasal obstruction impact breathing?
Episode also available on Apple Podcasts: https://apple.co/30PvU9C
#SnoringTreatment #AirwayHealth #DentalExperts
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https://www.youtube.com/watch?v=LW5a1X-sFSA
If our brains rely on thousands of different pathways to function, where do researchers even start for cognitive disease like Alzheimer's disease (AD)? It's as complicated as it sounds, but researcher Nikolaos Robakis is able to break the process down for listeners and offer insight on neurodegenerative diseases of the brain. Listen and learn
How there are two forms of Alzheimer's and what molecular biology techniques are used to study them, What role risk factors like diabetes and cardiovascular disease play, Why they've zeroed in on the mutation evident in familial Alzheimer's and what it might mean for both types, and What they hope to understand about the cascade that leads to neurodegeneration. Nikolaos K. Robakis is a professor of neuroscience and psychiatry at the Icahn School of Medicine at Mt. Sinai. He's also the A.P. Slaner Professor for Alzheimer's Disease Research. Fine-tuning the prevention and management of Alzheimer's disease relies on a clearer understanding of how the neurodegeneration develops, and that's where Dr. Robakis' work comes in. He explains that there are actually two forms of Alzheimer's disease: one is the genetic form, called familial Alzheimer's, and the other much more common type that has polymorphic causes is termed the sporadic familial form.
While previously it was thought plaques and tangles in the brain caused Alzheimer's, researchers like Robakis have found that's not necessarily true. By creating a model of familial Alzheimer's, which has a very simple one-gene mutation at its inception, he hopes to learn more about the cascade that leads to the neurodegeneration in both types. While they know about this amino acid mutation, they don't understand how it leads to neuronal death. He adds, "the central question is, what causes the acceleration in the neuronal death?" Listen in to find out what they think thus far and how this might contribute to better treatment for dementia patients. Episode also available on Apple Podcasts: apple.co/30PvU9C
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https://www.youtube.com/watch?v=cO_0Kng8S5U
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Chief Scientific Officer at Distributed Bio, Sawsan Youssef, joins the show to discuss her work at this unique company, and why it might hold promise for treating the COVID-19 virus and other medical conditions.
In this episode, you will learn:
1. What an antibody is, and how antibody therapeutics are developed
2. How antibody therapy might prevent the COVID-19 virus from binding to host cells, thereby preventing illness
3. How Distributed Bio identifies which antibodies will provide the most optimal binding properties at optimal binding sites for a given virus or disease
Distributed Bio is a small, self-funded biotechnology company that’s creating new technologies for therapeutics in a variety of medical fields by using immunology as the platform. There are two type of therapeutics in their current portfolio: one that relies on antibody generation, and one that is vaccine-based. In response to the COVID-19 pandemic, Distributed Bio is developing a therapeutic which is based on the use of antibodies.
Youssef explains the science and biology behind how antibody therapy works and why the use of antibodies to combat viruses is not only effective, but less likely to cause dangerous side effects. Generally speaking, antibodies are a good type of therapeutic because they are well-tolerated by the body and target precisely what you’re aiming for. In contrast, the use of other small molecules in therapeutics might target what you’re aiming for, but they may also target multiple other pathways in the body along the way, leading to adverse effects.
Youssef discusses a number of other important topics, including how this technology could treat autoimmune diseases like lupus, the role of antibody therapeutics in the field of oncology, in what ways some viruses are able to render binding antibodies ineffective, and the timeframe on the COVID-19 therapeutic that’s in the works.
Press play for all the details, and learn more about these technologies at https://www.distributedbio.com/.
Available on Apple Podcasts: apple.co/2Os0myK
#COVID19treatment #AnitibodyTherapeutics
#Findinggeniuspodcast #Healthpodcast #Medicinepodcast #Biosciencespodcast
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https://www.youtube.com/watch?v=1nb8_vSpQB8
CHECK OUT THE COMPLETE EPISODE ?
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How badly does distraction affect your performance?
You'd be surprised just how serious the repercussions of distraction can be, not just with your work productivity but your OVERALL performance.
This is something that my guest, New York Times bestseller Johann Hari, whose books, ‘Lost Connections’ and ‘Stolen Focus’ offer a wealth of insight and proof on topics that involve society, mental health issues, and the modern struggle against paying attention.
According to Johann, our prevailing lifestyle is bombarded with various forms of distractions, which makes paying attention and focusing DIFFICULT for us.
Do you resonate with this message? Share this video to raise awareness about how distraction affects productivity!
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https://www.youtube.com/watch?v=Z4S1rJNjkZU
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There are many factors that can contribute to the shift of a landscape.
In this video, my guest, Mikael Attal who lectures about Landscape Dynamics at the University of Edinburgh School of GeoSciences, discusses some of the factors that can cause a landscape to change over time. ?️
According to Mikael, natural events, like an earthquake will cause a landscape to change shape by starting a domino effect of events that can happen in a large range.
Have you ever witnessed any major change in a landscape after a natural event? Let us know in the comments.
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https://www.youtube.com/watch?v=Vtq2rkTxlbY
CHECK OUT THE COMPLETE EPISODE ?
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?️ Glaciers: Nature's Masterpieces! ?
Dr. Alexander Robel an Assistant Professor in the School of Earth and Atmospheric Sciences at Georgia Tech University explores the interesting fact that the composition of glaciers remains surprisingly similar, regardless of whether they terminate on land or in the salty depths of the ocean? It's all thanks to the snow that blankets them! ❄️
Discover more fascinating insights about glaciers in our latest episode! ??
Click the link in our bio or find it in the description above to listen to the full episode. Prepare to be amazed by the wonders of these icy giants! ?️❄️
Or Want to learn more about Dr. Robel and his research? Click https://iceclimate.eas.gatech.edu/ now!
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https://www.youtube.com/watch?v=9aCGvn0LpGI
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In addition to HIV prevention, one of the biggest topics for HIV research is finding a cure. While antivirals are able to control and suppress the virus, it’s still able to keep its foothold in infected subjects. This podcast talks to one researcher who's helped scientists understand that persistence.
Listen and learn
1. How HIV infection manifests as productive and latent infections,
2. What his study showed about the lack of viral evolution and means of proliferation, and
3. What stands as one of the more promising potentials for a cure, namely the "shock and kill" approach.
Matt Gartner is a research officer with Subbarao Group, researching common infectious diseases. His PhD work focused on infectious diseases microbiology, most specifically HIV. Like many infectious viruses, after the transmission of HIV, the virus usually undergoes a latent period.
However, the latent period has a couple of mysterious characteristics. Dr. Gartner studied the ability of HIV to establish a strong latent reservoir, which allows the virus to persist in people even if they're on antivirals. He explored two questions in his work: how does HIV establish this reservoir and how is this reservoir being maintained even under antiviral retro therapy.
His research found very little signs of virus evolution, suggesting the antiviral drugs are good at blocking replication. But they found a large percentage of sequences in the patient that were identical, which has important implications: this points to a proliferation of immune cells copying the same strain.
Dr. Gartner thinks that a patient's immune response helps the reservoir expand when it responds and replicates to attack a specific pathogen. As it replicates, it produces clones of the HIV retrovirus. While this means "any particular cure strategy will be very difficult to carry out," he discusses one that has potential called the "shock and kill" strategy. Listen in for more about this theory and other details on HIV infection mechanisms.
For more about his work, he suggests searching PubMed and ResearchGate.
Available on Apple Podcasts: apple.co/2Os0myK
#hiv #infectiousdiseases #Findinggeniuspodcast
#aids #hivawareness #hivpositive #medicine #virus #infection #healthcare #health #Healthpodcast #InternalMedicinepodcast #Biosciencespodcast
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https://www.youtube.com/watch?v=yXs4g4nvtgI