Yesterday's talk created lots of excitement and some confusion as well for the data that I shared from the Office of National Statistics (ONS) and from the Public Health England (PHE). I contacted PHE for their explanation of the data points. Let's review what they said.
Disclaimer: This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only. Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
Subscribe to the drbeen Channel HERE: http://bit.ly/2GBhiS0
For more content from drbeen, click HERE: http://bit.ly/2GB41bU
Watch drbeen videos HERE: http://bit.ly/2GB41bU
Like drbeen on Facebook HERE: http://bit.ly/2GSSTGS
Follow drbeen on Twitter HERE: http://bit.ly/2XeSVhV
Follow drbeen on Instagram HERE: http://bit.ly/2ST2Zih
Get new medical lectures across your devices. Stream anywhere, anytime. Try it for free! http://bit.ly/2QsIwQ5
Blood-cerebrospinal fluid (CSF) barrier is different from the blood-brain barrier.
In this brief video, we will discuss the composition of the blood-CSF barrier. This barrier is responsible to help create CSF.
We will discuss:
1. Capillaries and the tight junctions.
2. Ependymal cell modification at the blood-CSF barrier.
This video clip is part of the following lecture:
https://members.drbeen.com/view/cerebrospinal-fluid/S1WtXCIkE
Study well!
Love,
Mobeen
...
https://www.youtube.com/watch?v=C31VSw9R7WM
Israeli Study Shows 2nd Booster Efficacy Dwindles within 4 Weeks
Let's review the Israeli study published in the New England Journal of Medicine (NEJM) recording that the efficacy of the 4th vaccine dose dwindles within 4 weeks. This efficacy reduces to 10% within 8 weeks.
If you like this content and want more, I am doing a special lifetime membership offer. Click here:
https://www.drbeen.com/yt-special/
Want to support this work?:
Buy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed
Become my patron: https://www.patreon.com/mobeensyed?fan_landing=true
PayPal: https://paypal.me/mobeensyed?locale.x=en_US
#drbeen #koolbeens #COVID
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
DrBeen: Continuing Medical Education Online | USMLE Prep | CME and CE marketplace | Nurse Practitioner and Physician Assistant Training Programs | Medical Student Training
https://www.drbeen.com/
URL list from Wednesday, Apr. 6 2022
Israeli Study
https://www.nejm.org/doi/full/10.1056/NEJMoa2201570
PDF of the Israeli Study
https://www.nejm.org/doi/pdf/10.1056/NEJMoa2201570?articleTools=true
DrBeen: Continuing Medical Education Online | USMLE Prep | CME and CE marketplace | Nurse Practitioner and Physician Assistant Training Programs | Medical Student Training
https://www.drbeen.com/
Tracking an FDA advisory panel meeting on Covid vaccines and boosters
https://www.statnews.com/2022/04/06/tracking-fda-advisory-panel-meeting-covid-19-vaccines-boosters/
U.S. approves second Covid-19 booster for people 50 and older - STAT
https://www.statnews.com/2022/03/29/u-s-approves-second-covid-19-booster-for-people-50-and-older/
Protection by a Fourth Dose of BNT162b2 against Omicron in Israel | NEJM
https://www.nejm.org/doi/full/10.1056/NEJMoa2201570
U.S. FDA advisers weigh need for more COVID vaccine boosters
https://www.yahoo.com/news/u-fda-says-current-covid-133106704.html
U.S. FDA aims to decide on strain selection for COVID boosters by June | Reuters
https://www.reuters.com/world/us/us-fda-says-current-covid-vaccines-not-well-matched-against-ba2-variant-2022-04-06/
'We must adapt': CDC defends new isolation guidance amid omicron surge
https://www.yahoo.com/news/must-adapt-cdc-defends-isolation-195617194.html
Pfizer and BioNTech Omicron-targeted vaccine delayed - BioNTech CEO
...
https://www.youtube.com/watch?v=VcaSuGusQjw
Updated: Ivermectin Mechanism of Action (MOA)
More lectures on drbeen.com
Buy me a coffee :-)
https://www.buymeacoffee.com/DrMobeenSyed
Looking to support my educational work? Donate here:
https://paypal.me/mobeensyed?locale.x=en_US
Discuss various topics on DrBeen forum: https://members.drbeen.com/forum/600f000eb9bd47002acc9fae
The study that started it all.
The hero researchers are: Author links open overlay panel
LeonCalyaJulian D.DruceaMike G.CattonaDavid A.JansbKylie M.Wagstaffb
The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro
https://www.sciencedirect.com/science/article/pii/S0166354220302011
Ivermectin is a specific inhibitor of importin α/β-mediated nuclear importable to inhibit replication of HIV-1 and dengue virus
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3327999/
Ivermectin as an anti-inflammatory
https://pubmed.ncbi.nlm.nih.gov/19453757/
Ivermectin Docks to the SARS-CoV-2 Spike Receptor-binding Domain Attached to ACE2
https://iv.iiarjournals.org/content/34/5/3023
Ivermectin as a promising RNA-dependent RNA polymerase inhibitor and a therapeutic drug against SARS-CoV2: Evidence from in silico studies
https://www.researchsquare.com/article/rs-73308/v1
FLCCC site with more on Ivermectin
https://covid19criticalcare.com/i-mask-prophylaxis-treatment-protocol/faq-on-ivermectin/
#drbeen #koolbeens #COVID
...
https://www.youtube.com/watch?v=GZoBAuR4ajs
Researchers Show How SARS-COV-2 Spike Protein Causes Acute Lung Injury in Mice
First study in mice demonstrates that S1 part of the spike protein in combination with hACE2 enzyme triggers cytokine like storm and acute lung injury. Let's review this study.
Study: https://journals.physiology.org/doi/full/10.1152/ajplung.00223.2021
Study PDF: https://journals.physiology.org/doi/pdf/10.1152/ajplung.00223.2021
Buy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed
Become my patron: https://www.patreon.com/mobeensyed?fan_landing=true
Looking to support my educational work? Donate here: https://paypal.me/mobeensyed?locale.x=en_US
#drbeen #koolbeens #COVID
...
https://www.youtube.com/watch?v=BB9Tc6IEA4E
Will Summers Help Reduce Coronavirus Infections?
Good article
https://www.advisory.com/daily-briefing/2020/03/26/covid-summer
Tropical temperature is 64F or 18C and above
https://sciencing.com/meaning-tropical-climate-8722483.html
Humidity
https://www.weather.gov/lmk/humidity
Absolute humidity is the amount of water vapor in a cubic meter of the air.
30 grams per cubic meter is maximum
Relative humidity
It is a percentage of the amount of vapor at a specific temperature to the absolute humidity. For a cubic meter it is
Actual amount/Total amount that air can hold
Warm air can hold more.
Cooler air can hold less
Study in China before containment to see the spread in various cities that had differing temperatures.
March 9 2020
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3551767&fbclid=IwAR0JQJe3QxYsrP83RUDLsBnjZvLa5hkzoCAEvcsTbyuzI1xEQA8h3U7V7LM
Jan 21 to Jan 23 2020 (non intervened transmission.)
40 cases
1 degree C increase in temperature lowered R0 by 0.0225
1% increase in humidity lowered the R0 by 0.0158
Excerpt
the virus was more contagious in northern China, where temperatures and humidity were relatively low, and less contagious in the warmer and more humid cities in the country's southeast coast.
Temperature, Humidity and Latitude Analysis to Predict Potential Spread and Seasonality for COVID-19
March 5, 2020
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3550308&mod=article_inline
Excerpt
Sajadi said, "It couldn't have been bad luck that these particular places were hit." He explained, "This virus is acting like a seasonal respiratory virus. We could be wrong, but with the data we have, we think that is the most likely scenario."
Will Coronavirus Pandemic Diminish by Summer?
March 17, 2020
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3556998
83% of testing has been in non-tropical countries (30N and above).
90% of the cases are recorded in the range of 3C to 17C.
72% of the cases are in the areas with humidity between 3 to 9 g/m3.
Most tropical countries have not tested as extensively as northern countries. (Mobeen’s comment: what about China and South Korea? South Korea did a lot of testing. South Korea is 35.90N)
Several countries between 30N and 30S such as Australia, UAE, Qatar, Singapore, Bahrain, Qatar and Taiwan have performed extensive testing per capita and the number of positive 2019-nCoV cases per capita are lower in these countries compared to several European countries and the US.
Current data, although limited, suggests that it is extremely unlikely that the spread of 2019-nCoV would slow down in the USA or Europe, due to environmental factors, because a large number of cases have already been reported in the range of AH and T experienced by these regions for most part of the year.
i
...
https://www.youtube.com/watch?v=6Sa3RQVaMtE
How To Keep Your Brain Healthy - Part 1
Brain tissue health is an important aspect to consider while we age. In this series we will go over the paper The Sleeping Brain and the lifestyle choices the author has discussed.
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
URL list from Monday, Mar. 23 2023
The Sleeping Brain: Harnessing the Power of the Glymphatic System through Lifestyle Choices - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698404/
Sleep well — and reduce your risk of dementia and death - Harvard Health
https://www.health.harvard.edu/blog/sleep-well-and-reduce-your-risk-of-dementia-and-death-2021050322508
APOE ε4, Alzheimer’s disease neuropathology and sleep disturbance, in individuals with and without dementia | Alzheimer's Research & Therapy | Full Text
https://alzres.biomedcentral.com/articles/10.1186/s13195-022-00992-y
N3 Phase of Sleep.
https://chat.openai.com/chat
Understanding Delta Brain Waves And Sleep
https://www.sixstepstosleep.com/understanding-delta-brain-waves/
N3: Slow Wave Sleep | Sleepopolis
https://sleepopolis.com/education/n3-slow-wave-sleep/
Stage N3 of sleep. Delta waves on EEG recordings are observed. | Download Scientific Diagram
https://www.researchgate.net/figure/Stage-N3-of-sleep-Delta-waves-on-EEG-recordings-are-observed_fig4_280558638
A 30-second Epoch consisting of the parameters of staging sleep... | Download Scientific Diagram
https://www.researchgate.net/figure/4-A-30-second-Epoch-consisting-of-the-parameters-of-staging-sleep-electroencephalogram_fig4_282014972
Hallmark of Stage N3 (slow-wave sleep or Stages 3 and 4 sleep: delta... | Download Scientific Diagram
https://www.researchgate.net/figure/Hallmark-of-Stage-N3-slow-wave-sleep-or-Stages-3-and-4-sleep-delta-waves_fig1_5812861
Frontiers | Perivascular Spaces, Glymphatic System and MR
https://www.frontiersin.org/articles/10.3389/fneur.2022.844938/full
Perivascular spaces and brain waste clearance systems: relevance for neurodegenerative and cerebrovascular pathology | SpringerLink
https://link.springer.com/article/10.1007/s00234-021-02718-7
Frontiers | Perivascular Unit: This Must Be the Place. The Anatomical Crossroad Between the Immune, Vascular and Nervous System
https://www.frontiersin.org/articles/10.3389/fnana.2020.00017/full
Neuroglia Lab : Glymphatics and virchow-robin space
http://visnu528.blogspot.com/2014/09/glymphatics-and-virchow-robin-space.html
Physiology and Clinical Relevance of Enlarged Perivascular Spaces in the Aging Brain | Neurology
https://n.neurology.org/content/98/3/107
Aquaporin-4 - Wikipedia
https://en.wikipedia.org/wiki/Aquaporin-4
Astrocyte - Wikipedia
https://en.wikipedia.org/wiki/Astrocyte
Neurocytology-Astrocytes
https://neuropathology-web.org/chapter1/chapter1bAstrocytes.html#:~:text=Astrocytic%20foot%20processes%20surround%20brain,maintains%20homeostasis%20in%20the%20CNS.
Blood-brain barrier | RIT
https://www.rit.edu/spotlights/blood-brain-barrier
The Blood-Brain Barrier | Morphology of Nervous System
https://sisu.ut.ee/histology/blood-brain-barrier
Elimination of substances from the brain parenchyma: efflux via perivascular pathways and via the blood–brain barrier | Fluids and Barriers of the CNS | Full Text
https://fluidsbarrierscns.biomedcentral.com/articles/10.1186/s12987-018-0113-6
The glymphatic systems in the brain and the eye export fluid and... | Download Scientific Diagram
https://www.researchgate.net/figure/The-glymphatic-systems-in-the-brain-and-the-eye-export-fluid-and-solutes-from_fig1_353240231
External Carotid Artery: Anatomy & Branches | Study.com
https://study.com/academy/lesson/external-carotid-artery-anatomy-branches.html
Cervical Node Mets fron Occult Primary
http://www.aboutcancer.com/cervical_node_occult_utd_907.htm
...
https://www.youtube.com/watch?v=rJ292bs8-7Y
Random Chit Chat with Dr. Been (#5)
More lectures on drbeen.com
Buy me a coffee :-)
https://www.buymeacoffee.com/DrMobeenSyed
Looking to support my educational work? Donate here:
https://paypal.me/mobeensyed?locale.x=en_US
Discuss various topics on DrBeen forum: https://members.drbeen.com/forum/
#drbeen #koolbeens #COVID
...
https://www.youtube.com/watch?v=SA0VcO17npI
Vaccine Spike vs. SARS-COV-2 Spike
There has been a lot of discussion for the spike and ACE2 binding. I have recorded many talks on this topic as well. However, an important piece missing for us has been to understand the difference of the spike between the vaccine and the virus. Let's review these differences.
If you like this content and want more, I am doing a special one-time membership offer. Click here: https://www.drbeen.com/yt-special/
Want to support this work?:
Buy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed
Become my patron: https://www.patreon.com/mobeensyed?fan_landing=true
PayPal: https://paypal.me/mobeensyed?locale.x=en_US
My substack: https://mobeensyedmd.substack.com/
#drbeen #koolbeens #COVID
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
URL list from Thursday, Nov. 17 2022
DrBeen: Medical Education Online
https://www.drbeen.com/
SARS-CoV-2 spike protein: pathogenesis, vaccines, and potential therapies | SpringerLink
https://link.springer.com/article/10.1007/s15010-021-01677-8
SARS-CoV-2 structural features may explain limited neutralizing-antibody responses | npj Vaccines
https://www.nature.com/articles/s41541-020-00264-6
SARS-CoV-2 spike behavior in situ: a Cryo-EM images for a better understanding of the COVID-19 pandemic | Signal Transduction and Targeted Therapy
https://www.nature.com/articles/s41392-020-00365-7
Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen | PNAS
https://www.pnas.org/doi/10.1073/pnas.1707304114
An mRNA Vaccine against SARS-CoV-2 — Preliminary Report | NEJM
https://www.nejm.org/doi/full/10.1056/NEJMoa2022483
Structure-based design of prefusion-stabilized SARS-CoV-2 spikes - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402631/
SARS-CoV-2 prefusion spike protein stabilized by six rather than two prolines is more potent for inducing antibodies that neutralize viral variants of concern | PNAS
https://www.pnas.org/doi/full/10.1073/pnas.2110105119
Frontiers | Enhancing the Prefusion Conformational Stability of SARS-CoV-2 Spike Protein Through Structure-Guided Design
https://www.frontiersin.org/articles/10.3389/fimmu.2021.660198/full
Closing coronavirus spike glycoproteins by structure-guided design - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302216/
Prefusion Coronavirus Spike Proteins and Their Use | Technology Transfer
https://www.techtransfer.nih.gov/bundle/tab-3261
Locking Down Shape-Shifting Spike Protein Aids Development of COVID-19 Vaccine - UT News
https://news.utexas.edu/2020/08/05/locking-down-shape-shifting-spike-protein-aids-development-of-covid-19-vaccine/
SARS-CoV-2 S protein:ACE2 interaction reveals novel allosteric targets | eLife
https://elifesciences.org/articles/63646
Epitope - Wikipedia
https://en.wikipedia.org/wiki/Epitope
...
https://www.youtube.com/watch?v=XCmZSu1GrjY
Subscribe to the drbeen Channel HERE: http://bit.ly/2GBhiS0
For more content from drbeen, click HERE: http://bit.ly/2GB41bU
Watch drbeen videos HERE: http://bit.ly/2GB41bU
Like drbeen on Facebook HERE: http://bit.ly/2GSSTGS
Follow drbeen on Twitter HERE: http://bit.ly/2XeSVhV
Follow drbeen on Instagram HERE: http://bit.ly/2ST2Zih
Get new medical lectures across your devices. Stream anywhere, anytime. Try it for free! http://bit.ly/2QsIwQ5
Which immune cells are responsible for handling Muco-Cutaneous vs. Systemic Candidiasis?
...
https://www.youtube.com/watch?v=3dR0UJ-ZwsA