Incurable Cancer Cleared in A Teenager - Let's See How
A Teenage Girl's Incurable Cancer is Cured
A teenage girl Alyssa with an incurable leukemia was given a 3 base edited CAR-T cell intervention. Six months after she has no signs of cancer any more. Let's look at the technology and its application.
Disclaimer: This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only. Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
David R. Liu on Twitter: "Alyssa, a 13-year old T-cell leukemia (ALL) patient in the UK, was the first person to receive a base editing therapeutic—T cells with three base edits—and the first patient reported to benefit from base editing: complete remission, 6 months later. 1/3 https://t.co/CgL6mD6U7B" / Twitter https://twitter.com/davidrliu/status/1601770994070597632
Causes of Death in Childhood Acute Lymphoblastic Leukemia at Hue Central Hospital for 10 Years (2008-2018) - PMC https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977218/#:~:text=Infection%20is%20the%20major%20cause,especially%20prevention%20and%20control%20infection.
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Dr. Mobeen presents a review of Immunology.
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https://www.youtube.com/watch?v=xHw_zJRqPtc
Molnupiravir, Bamlanivimab, Remdesivir, and Ivermectin Studies
If authorized/approved, Merck's Molnupiravir is an excellent new addition to the toolset for the physicians to manage COVID-19. I believe this will be the last straw for the SARS-COV-2 to become an endemic from a pandemic. Let's review the timeline, trial, order placement, and possibly imminent EUA as compared to other drugs like Bamlanivimab, etc.
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Molnupiravir information and the study that is the basis for its possible EUA.
https://www.merck.com/news/merck-and-ridgebacks-investigational-oral-antiviral-molnupiravir-reduced-the-risk-of-hospitalization-or-death-by-approximately-50-percent-compared-to-placebo-for-patients-with-mild-or-moderat/
https://www.drugs.com/history/molnupiravir.html
https://clinicaltrials.gov/ct2/show/study/NCT04575597?term=molnupiravir&draw=2&rank=2
https://en.wikipedia.org/wiki/Molnupiravir
https://engagezone.msd.com/doc/ProcedureAccessClinicalTrialData.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8277160/
Some studies for other drugs
https://ivmmeta.com/#fig_fpr
https://journals.sagepub.com/doi/10.1177/03000605211013550
https://clinicaltrials.gov/ProvidedDocs/31/NCT04523831/Prot_ICF_000.pdf
https://pubmed.ncbi.nlm.nih.gov/20946067/
https://pubmed.ncbi.nlm.nih.gov/32251768/
WHO study showing no benefit of Remdesivir
https://www.bmj.com/content/371/bmj.m4057
Another analysis finds ambiguous or no effect of Remdesivir
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0255093
A good message from Dr. Eric Osgood in response to an analysis of a drug:
https://mobile.twitter.com/gidmk/status/1412635825771192320
Bamlanivimab trial:
https://www.fda.gov/drugs/drug-safety-and-availability/fda-authorizes-bamlanivimab-and-etesevimab-monoclonal-antibody-therapy-post-exposure-prophylaxis
References in the order I displayed:
https://mobile.twitter.com/gidmk/status/1412635825771192320
https://pubmed.ncbi.nlm.nih.gov/20946067/
https://www.fda.gov/drugs/drug-safety-and-availability/fda-authorizes-bamlanivimab-and-etesevimab-monoclonal-antibody-therapy-post-exposure-prophylaxis
https://www.fda.gov/news-events/press-announcements/fda-approves-first-treatment-covid-19
https://jamanetwork.com/journals/jama/fullarticle/2775647
https://www.cdc.gov/coronavirus/2019-ncov/variants/delta-variant.html?s_cid=11609:vaccine%20efficacy%20against%20delta%20variant:sem.ga:p:RG:GM:gen:PTN.Grants:FY22
https://www.medrxiv.org/content/10.1101/2021.06.28.21259420v3
https://clinicaltrials.gov/ct2/show/study/NCT04575597?term=molnupiravir&draw=2&rank=2
h
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https://www.youtube.com/watch?v=mSgZfMHJUpQ
Omicron - Good News Continues (60% Less Risk of Hospitalization by Omicron as Compared to Delta - Studies roundup)
Let's review the latest studies about the risk of hospitalization, the severity of the disease, and the risk in previously infected, vaccinated vs. unvaccinated.
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
References Thursday, Dec. 23 2021 16:37 PM
HKUMed finds Omicron SARS-CoV-2 can infect faster and better than Delta in human bronchus but with less severe infection in lung - News | HKUMed
https://www.med.hku.hk/en/news/press/20211215-omicron-sars-cov-2-infection
Severity of Omicron variant of concern and vaccine effectiveness against symptomatic disease: national cohort with nested test negative design study in Scotland — University of Edinburgh Research Explorer
https://www.research.ed.ac.uk/en/publications/severity-of-omicron-variant-of-concern-and-vaccine-effectiveness-
Early assessment of the clinical severity of the SARS-CoV-2 Omicron variant in South Africa | medRxiv
https://www.medrxiv.org/content/10.1101/2021.12.21.21268116v1
Early assessment of the clinical severity of the SARS-CoV-2 Omicron variant in South Africa
https://www.medrxiv.org/content/10.1101/2021.12.21.21268116v1.full.pdf
Report 49 - Growth, population distribution and immune escape of Omicron in England | Faculty of Medicine | Imperial College London
https://www.imperial.ac.uk/mrc-global-infectious-disease-analysis/covid-19/report-49-Omicron/
Report 50 - Hospitalisation risk for Omicron cases in England | Faculty of Medicine | Imperial College London
https://www.imperial.ac.uk/mrc-global-infectious-disease-analysis/covid-19/report-50-severity-omicron/
2021-12-22-COVID19-Report-50.pdf
https://www.imperial.ac.uk/media/imperial-college/medicine/mrc-gida/2021-12-22-COVID19-Report-50.pdf
omicron spike protein less efficient gupta labs - Google Search
https://www.google.com/search?q=omicron+spike+protein+less+efficient+gupta+labs&ei=kAfFYf-vH8nVtAbCvZHgBA&ved=0ahUKEwj_t7P1ivv0AhXJKs0KHcJeBEwQ4dUDCA4&uact=5&oq=omicron+spike+protein+less+efficient+gupta+labs&gs_lc
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https://www.youtube.com/watch?v=VfF43zt42Jw
Pfizer Vaccine For Kids 12 Years and Above Granted EUA By FDA
Pfizer-BioNTech COVID vaccine received FDA’s emergency use authorization for adolescents age 12-15 on 10th May 2021. Let’s review the trial results, dosing, and side effects.
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Coronavirus (COVID-19) Update: FDA Authorizes Pfizer-BioNTech COVID-19 Vaccine for Emergency Use in Adolescents in Another Important Action in Fight Against Pandemic
https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-authorizes-pfizer-biontech-covid-19-vaccine-emergency-use
Document for the providers
https://www.fda.gov/media/144413/download
PFIZER-BIONTECH ANNOUNCE POSITIVE TOPLINE RESULTS OF PIVOTAL COVID-19 VACCINE STUDY IN ADOLESCENTS
https://www.pfizer.com/news/press-release/press-release-detail/pfizer-biontech-announce-positive-topline-results-pivotal
Dec 10th EUA for Pfizer that included authorization for 16 years and above
https://www.fda.gov/media/144245/download
#drbeen #koolbeens #COVID
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https://www.youtube.com/watch?v=c8rZJT-hVCk
MATH++ Part 2
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What are histiocytes? (Macrophages and Dendritic cells in the tissues and monocytes in the blood.)
https://en.wikipedia.org/wiki/Histiocyte#:~:text=A%20histiocyte%20is%20a%20vertebrate,of%20the%20organism's%20immune%20system.
What is macrophage activation syndrome?
Overactivity of the macrophages that upregulates the immune system. Sort of a cytokine storm.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124446/
What is Sepsis? Increased breathing rate, impaired consciousness, low blood flow
https://en.wikipedia.org/wiki/Sepsis
What is ferritin? A protein that binds with ferric inside the cells to store it.
https://en.wikipedia.org/wiki/Ferritin
How do steroids suppress inflammation?
https://www.frontiersin.org/articles/10.3389/fendo.2018.00235/full
Type I interferons
https://en.wikipedia.org/wiki/Interferon_type_I
Type II interferons
https://en.wikipedia.org/wiki/Interferon_type_II
Interleukin 6 Actions.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176007/
Lactate dehydrogenase
https://en.wikipedia.org/wiki/Lactate_dehydrogenase
MATH+ is a fascinating protocol. We have added another plus to it to add some of our modifications.
Here is the link to the protocol: https://www.evms.edu/media/evms_public/departments/internal_medicine/EVMS_Critical_Care_COVID-19_Protocol.pdf
Protocol refers the L-Type and H-Type phenotypes of the COVID-19 patients. Here is a link to these types and the mechanics:
https://pulmccm.org/ards-review/covid-19-associated-ards-cards-the-l-phenotype/
Here is a link showing that if we ventilate an L-Type phenotype patients then we add to their dead space.
https://pulmccm.org/ards-review/icu-physiology-1000-words-high-flow-oxygen-therapy/
What does the recruitability of the lungs mean? Simply opening up the closed alveoli
https://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-020-00675-7
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https://www.youtube.com/watch?v=qmGxrAyGJ6I
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Fundamentals of the Renal System are important concepts to grasp, for both health professionals and patients of Renal Diseases. This series covers the fundamentals necessary for USMLE students.
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https://www.youtube.com/watch?v=l8XhZiChjh4
This Study Can Help FDA Rework Their Vaccine Analysis
In this study the researchers rework the vaccine safety analysis from the data published in the trial briefs. I think they have some hints for FDA to use. Let's review.
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
URL list from Friday, Sep. 2 2022
Serious adverse events of special interest following mRNA COVID-19 vaccination in randomized trials in adults - ScienceDirect
https://www.sciencedirect.com/science/article/pii/S0264410X22010283
Covid: Pregnant women targeted with false vaccine claims - BBC News
https://www.bbc.com/news/health-62739554?at_medium=RSS&at_campaign=KARANGA
Vaccines and Related Biological Products Advisory Committee June 28, 2022 Meeting Briefing Document- FDA
https://www.fda.gov/media/159452/download
Coronavirus (COVID-19) Update: FDA Authorizes Moderna, Pfizer-BioNTech Bivalent COVID-19 Vaccines for Use as a Booster Dose | FDA
https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-authorizes-moderna-pfizer-biontech-bivalent-covid-19-vaccines-use
Coronavirus (COVID-19) Update: FDA Recommends Inclusion of Omicron BA.4/5 Component for COVID-19 Vaccine Booster Doses | FDA
https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-recommends-inclusion-omicron-ba45-component-covid-19-vaccine-booster
Microsoft Word - SO2_D2.1.3_COVID-19_AESI update_V1.0_Part 2_09Nov2021.docx
https://brightoncollaboration.us/wp-content/uploads/2021/11/SO2_D2.1.3_COVID-19_AESI-update_V1.0_Part-2_09Nov2021.pdf
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https://www.youtube.com/watch?v=9IOqH_QAK0k
Spike Protein from Infection or Vaccine Can Be Problematic for Some (An Article Review)
Researchers from UC Davis and Harvard have written an article published in NEJM about the role of anti-idiotype antibodies possibly causing autoimmune disease in some individuals. They think that the network hypothesis formulated by Neil K Jerne (a Nobel Laureate) maybe at play. Let's review.
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Reference List from Monday, Dec. 27 2021
Antibodies mimicking the virus may explain long haul COVID-19, rare vaccine side effects
https://health.ucdavis.edu/newsroom/news/headlines/antibodies-mimicking-the-virus-may-explain-long-haul-covid-19-rare-vaccine-side-effects/2021/11
A Possible Role for Anti-idiotype Antibodies in SARS-CoV-2 Infection and Vaccination | NEJM
https://www.nejm.org/doi/full/10.1056/NEJMcibr2113694
Niels K. Jerne - Facts
https://www.nobelprize.org/prizes/medicine/1984/jerne/facts/
Niels Jerne - Explaining the Human Immune System - SciHi BlogSciHi Blog
http://scihi.org/niels-jerne-immune-system/
Niels K. Jerne - Nobel Lecture: The Generative Grammar of the Immune System - NobelPrize.org
https://www.nobelprize.org/prizes/medicine/1984/jerne/lecture/
César Milstein - Nobel Lecture: From the Structure of Antibodies to the Diversification of the Immune Response
https://www.nobelprize.org/prizes/medicine/1984/milstein/lecture/
Epitope Selection - immunoGlobe GmbH - Your Antibody Manufacturer & Service Provider
https://www.immunoglobe.com/epitope-selection.html
Epitope - Wikipedia
https://en.wikipedia.org/wiki/Epitope
#drbeen #koolbeens #COVID
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
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https://www.youtube.com/watch?v=kE9UUX7NV5Q