Just over a century ago in 1918–1919, the “Spanish” flu pandemic appeared nearly simultaneously around theworld and caused extraordinary mortality, estimated at 50–100 million fatalities. The pandemic’s sudden appearance and high fatality rate were unprecedented, and 100 years later still serve as a stark reminder of the continual threat influenza poses. Sequencing and reconstruction of the 1918 virus have allowed scientists to answer many questions about its origin and pathogenicity, although many questions remain.
The 1918 Influenza Pandemic and Its Legacy
Taubenberger, J.K. et al. 2020
doi://10.1101/cshperspect.a038695
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