Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional. ... https://www.youtube.com/watch?v=sMqLZmZGZjA
Green Tea (EGCG) Zinc Ionophores, Nasal Sprays, Kinin B2 Receptor Antagonists
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Epigallocatechin-gallate (from Green Tea) is a Zinc ionophore just like Quercetin and Hydroxychloroquine
https://pubs.acs.org/doi/10.1021/jf5014633
The experiment in the link above used FluoZin indicator for Zn2+
https://www.thermofisher.com/order/catalog/product/F24195#/F24195
Nasal spray of TLR2 agonist reduces viral load by 96% in throat swabs and 93% in the nasal swabs of ferrets
https://www.biorxiv.org/content/10.1101/2020.09.25.309914v1.full
Bradykinin B2 Receptor Antagonist (icatibant) helps reduce the oxygen requirement
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2769237
Icatibant
https://en.wikipedia.org/wiki/Icatibant
Our video on bradykinin storm
https://youtu.be/tDbRfur36sE
...
https://www.youtube.com/watch?v=wmGYsgrquMM
Bromhexine Study, SARS-COV-2 Antibody Cocktail
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Bromhexine - small study finds it effective for reducing mortality and morbidity in the severe SARS-COV-2 patients
https://bi.tbzmed.ac.ir/Article/bi-23240
Antibody cocktail
https://investor.regeneron.com/news-releases/news-release-details/regenerons-regn-cov2-antibody-cocktail-reduced-viral-levels-and
https://science.sciencemag.org/content/369/6506/1010
https://science.sciencemag.org/content/sci/369/6506/1010.full.pdf
...
https://www.youtube.com/watch?v=FMc7B_d2TV4
Neutrophils have a multilobed nucleus with 3-4 lobes. They contain primary, secondary, and tertiary granules, each has a different set of enzymes which help neutrophils defending us.
Interleukin-3 released by the T cells act on the hemocytoblasts.
The second messenger signal goes to the nucleus, the genes become active, and mitosis occurs.
So, interleukin-3 acts on the hemocytoblast cells and increases the production of all the blood cells.
Interleukin-3 causes the formation of myeloid progenitor cells, which form myeloblast.
Dr. Mobeen Syed discusses that there are chemical substances that act on myeloblasts and cause an increase in the production of Granulocytes and Monocytes. These are called granulocyte-monocyte colony-stimulating factors.
The cells which respond to colony-forming factor and divide are called colony-forming units.
Granulocytes-colony-stimulating factors excite an increase in the production of eosinophils, basophils, and neutrophils (for example, in acute infections).
Monocytes-colony-stimulating factors cause the increased production of monocytes and macrophages (for example, in chronic infections).
Macrophages release colony-stimulating factors that transmit signals to the bone marrow and result in increased production of Granulocytes and Monocytes.
The following topics have discussed in the full video:
* Granules in the neutrophils
* Effect of IL 3 on hemocytoblasts
* Granulocytes-monocytes colony-stimulating factors
* Granulocytes-colony-stimulating factors
* Monocytes colony-stimulating factors
* Role of macrophage in increased production of white blood cells
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https://www.youtube.com/watch?v=c6IApYNdh90
Your COVID-19 Questions Answered (Open Forum Feb 8th 2021)
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Discuss various topics on DrBeen forum: https://members.drbeen.com/forum/
Twitter link
https://twitter.com/drbeen_medical/status/1357412426057060353?s=20
Fluvoxamine reduces COVID symptoms
https://jamanetwork.com/journals/jama/fullarticle/2773108
Can MMR vaccine be protective (according to this analysis and exploration)?
https://capitolfax.com/2021/02/04/an-interesting-hypothesis-but-no-definitive-proof-yet-about-the-mmr-vaccine-and-covid-19/
Low serotonin levels cause depression
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471964/
SSRIs like Fluvoxamine help keep Serotonin in the synapses for a longer period of time
https://pubchem.ncbi.nlm.nih.gov/compound/Fluvoxamine#section=Metabolism-Metabolites
How will the mRNA from the vaccine degrade?
DrBeen video
https://youtu.be/SQztlqblgVI
Do increased B vitamin levels have something to do with the long-haul syndrome?
https://en.wikipedia.org/wiki/B_vitamins
Antiphospholipid antibodies and COVID-19
https://www.nhlbi.nih.gov/health-topics/antiphospholipid-antibody-syndrome
https://www.hss.edu/conditions_top-ten-series-antiphospholipid-syndrome-coronavirus-covid-19.asp
Maybe, may not be
https://pubmed.ncbi.nlm.nih.gov/33328777/
Do we need to pay for the submissions in journals?
https://www.editage.com/insights/do-i-have-to-pay-for-submitting-an-article-to-a-journal-regardless-of-whether-it-is-accepted-or-not
https://authors.bmj.com/open-access/fees-waivers/
https://www.thelancet.com/langlo/about
Does Novavax use Saponin adjuvant? (yes)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899102/pdf/12026_2018_Article_8991.pdf
https://www.precisionvaccinations.com/vaccines/nvx-cov2373-covid-19-vaccine
What are saponins?
https://en.wikipedia.org/wiki/Saponin
Do all RNA viruses have RdRp?
https://en.wikipedia.org/wiki/RNA-dependent_RNA_polymerase
RdRp blockers
Zinc
Favipiravir
Ivermectin
Ivermectin can cause testicular dysfunction
https://www.sciencedirect.com/science/article/pii/S0753332220300317
Mouth washes that may inactivate COVID
https://youtu.be/wSqT6vHTMzg
Latest studies on asymptomatic transmission?
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2774707
#drbeen #koolbeens #COVID
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https://www.youtube.com/watch?v=fd5TxSU7kdQ
Daily Mini Been is here!
Repairing skin lacerations can be tricky and the results are there for all to see. Dr Zeshaan Maan, plastic surgery resident, gives a quick overview of laceration repair.
Check out his full length webinar at DrBeen.com
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#DrBeen #surgery #plasticsurgery #laceration #suture #lacerationrepair #stitch #medlife #scrublife #residency #doctor #nurse #nursing #nursingschool #nursepractitioner #np #nurselife #pa #physicianassistant #medicalschool #medschool #medicalstudent #premed #physician #MD #plasticsurgery #keeppushing #aimhigh #medicaleducation #education @drzmaan
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https://www.youtube.com/watch?v=8RRJSKGqP5U
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Embryology and fate of the pharyngeal arch arteries.
Aortic Sac.
Truncus Arteriosus.
Dorsal Aorta
3rd Pharyngeal Arch
4th Pharyngeal Arch
6th Pharyngeal Arch
...
https://www.youtube.com/watch?v=D_O28RjU94U
Random COVID Questions with Dr. Been (#153)
Happy Thanksgiving all. Let's have fun and talk :-)
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#drbeen #koolbeens #COVID
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
...
https://www.youtube.com/watch?v=dgUse3GdxwE
Which Vaccine Is Better?
UK approves Pfizer/BioNTech vaccine. They become the first country in the world to approve a vaccine outside of the trials.
https://www.bbc.com/news/health-55145696
Pfizer/BioNTech vaccine was submitted to FDA for approval on 10th November 2020. Expected meeting to review and possibly approve is 10th December 2020 (US.)
https://www.pfizer.com/news/press-release/press-release-detail/pfizer-and-biontech-conclude-phase-3-study-covid-19-vaccine
Moderna’s vaccine is also submitted for the FDA approval on 30th November. Expected FDA meeting to review and possibly approve is 17th December.
https://investors.modernatx.com/news-releases/news-release-details/moderna-announces-primary-efficacy-analysis-phase-3-cove-study
Ultra-cold storage requirements
https://www.reuters.com/article/health-coronavirus-vaccines-distribution/why-pfizers-ultra-cold-covid-19-vaccine-will-not-be-at-the-local-pharmacy-any-time-soon-idUSKBN27P2VP
Vaccine storage requirements and logistics.
https://www.paho.org/immunization/toolkit/resources/partner-pubs/ebook/Chapter5-Vaccine-Storage-and-Handling.pdf?ua=1
For fun here is a good link to read-up on the physics of the ultra-cold storage units.
https://www.wired.com/story/physics-of-materials-minus-80-degrees-celsius/
A good discussion about the cold-storage needs
https://www.nbcphiladelphia.com/news/coronavirus/70-degrees-how-philly-plans-to-store-a-covid-19-vaccine-that-must-be-kept-ultra-cold/2592559/
WHO’s guidelines for cold-chain logistics
https://www.who.int/immunization/documents/IIP2015_Module2.pdf
...
https://www.youtube.com/watch?v=0eb5zJhKd6k
Muscle Pain - Pain Lecture 2
In 2021 about 56 million US adults experienced chronic pains. 17 million experienced high-impact chronic pains. Pandemic has contributed to a significant new cases. This is the second part of the series to understand what pain is, the anatomy, physiology, pathology, and the management aspects will be covered in this mini-series on pain. Today we will discuss the fundamentals of muscle pain.
If you like this content and want more, I am doing a special lifetime membership offer. Click here:
https://www.drbeen.com/yt-special-p/
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#drbeen #koolbeens #PAIN
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
URL list from Friday, Nov. 10 2023 17:12 PM
Muscle Pain: Mechanisms and Clinical Significance - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696782/
Pathophysiology of musculoskeletal pain: a narrative review - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7934019/#:~:text=The%20pathogenic%20mechanisms%20of%20musculoskeletal,nervous%20system%20cells%20and%20mediators.
Pathophysiology of skeletal muscle disturbances in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) | Journal of Translational Medicine | Full Text
https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-021-02833-2#Abs1
Cell Membrane Steady Potential - an overview | ScienceDirect Topics
https://www.sciencedirect.com/topics/neuroscience/cell-membrane-steady-potential#:~:text=Decreased%20cell%20potassium%20content%20has,develop%20weakness%20and%20muscle%20paralysis.
...
https://www.youtube.com/watch?v=GgBUz_QQIjI