Source: Impact of population mixing between vaccinated and unvaccinated subpopulations on infectious disease dynamics: implications for SARS-CoV-2 transmission https://www.cmaj.ca/content/cmaj/194/16/E573.full.pdf From the study: Limitations The simplicity of our model is both a strength (it is transparent and easily modified to explore the impact of uncertainty) and a weakness, because it does not precisely simulate a real-world pandemic process in all its complexity. For instance, we modelled vaccine effectiveness against infection but not the additional benefits of vaccination for preventing severe illness. Although this benefit is not captured by a simple model focused on transmission, an advantage of models such as ours is that they provide a ready platform for layering on increasing complexity, so our model can be adapted or expanded to consider impacts on the health system, or to incorporate additional structural elements or alternate assumptions. We have also likely underestimated vaccine benefit in this model, as we have not attempted to capture the impact of vaccines on prevention of forward transmission by vaccinated, infected individuals; this effect appears to be substantial.

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