Shervin Takyar is an associate professor at Yale School of Medicine and practicing pulmonologist who joins the show to discuss his experience with cancer, both in research and in the clinic. His work is focused primarily on endothelium, which is an important part of the tumor microenvironment, and also on what happens before cancer develops, rather than what to do once it has. ... https://www.youtube.com/watch?v=1mCymjTLkDk

Our Website: https://www.findinggeniuspodcast.com/ Subscribe and review our Podcast on iTunes: https://apple.co/2L6tN88 Follow us on: Facebook: https://web.facebook.com/futuretechpodcast/ Twitter: https://twitter.com/finding_genius Instagram: https://www.instagram.com/findinggeniuspodcast/ Professor Robert Poulin’s interests center around how and in what ways parasites manipulate the behavior of their hosts. He joins the show to discuss his fascinating research. In this episode, you will learn: 1. Why a parasite would benefit from making its host insect take on the appearance of a bright red berry 2. How an examination of the brain cells of infected insects could shed light on the pathways by which host behaviors change 3. How a parasite’s microbiome and the genomes of the microbes within it could help explain the mechanisms underlying parasite-driven behavioral modification of hosts Over the course of millions of years, parasitism has been gradually shaped and enhanced by evolution, resulting in parasites that have the amazing ability to induce behavioral and physical modifications in their hosts in ways that ultimately benefit the parasite. Consider, for instance, the hairworm, which is a parasite that grows inside a terrestrial insect in coil-like fashion until it becomes two to three feet in length, at which point it induces the insect to essentially commit suicide for its survival; the hairworm causes the insect to search for and jump into a body of water, where the hairworm can then emerge from the parasite (killing it in the process), find a mate, and reproduce. This is just one example of a parasitic relationship that Poulin hopes to better understand. In part, his research involves an examination of gene expression within the genome of the brain cells of infected host insects. Poulin is also interested in other mechanisms by which parasites manipulate hosts, such as those that may involve the microbes that parasites carry with them, or the presence of symbiotic viruses that manipulate host behavior. Among other topics, Poulin discusses how parasites are so effective at evading host immune systems, counter-adaptations to host defenses, examples of how parasites can form part of a larger ecosystem, which tissues are preferential for parasites to reside in and why, and so much more. Tune in for all the details and learn more about Poulin’s research by visiting https://www.otago.ac.nz/parasitegroup/home.html. Available on Apple Podcasts: apple.co/2Os0myK #Parasites #BehavioralModification #Findinggeniuspodcast #Healthpodcast #Medicinepodcast #Biosciencespodcast ... https://www.youtube.com/watch?v=IJxscSXmmq0

Our Website: https://www.findinggeniuspodcast.com/ Subscribe and review our Podcast on iTunes: https://apple.co/2L6tN88 Follow us on: Facebook: https://web.facebook.com/futuretechpodcast/ Twitter: https://twitter.com/finding_genius Instagram: https://www.instagram.com/findinggeniuspodcast/ Daniel Heller runs a lab developing nanomaterials for the treatment and detection of cancer and other diseases. He explains this technology by describing 1. The research tools used to try and improve biological systems testing in general, 2. Specific nanotechnology designed to detect the signs of cancer, especially ovarian, much earlier than current tests, and 3. The movement towards fitness tracker paradigms for noninvasive medical detectors. Daniel A. Heller, PhD, runs the Daniel Heller Lab at Memorial Sloan Kettering Cancer Center. They're making sensors to detect signs of cancer at the earlies stages, like ovarian cancer, which is often detected at later stages when it is hardest to treat. Currently, they're creating sensors that would be implanted in patients at higher risk to detect ovarian cancer. He explains that the sensors identify biomarkers, which appear at higher levels in certain areas of the body like fallopian tubes, for example, before they appear in the blood where they are normally detected but too late for effective treatment. He explains that nanotechnologists are working alongside the popularity of fitness trackers like the Apple watches, hoping to merge that trend with medical advancement. These trackers shoot light to measure bodily functions like your pulse. Heller and his colleagues thought that they could get at these key biomarkers through something similar, a wearable device, which can use light to compare and measure indicators but noninvasively. A nanotube in the body can send infrared signals to this wearable device. He describes how these can offer an accumulative measure—so even if the cancer is at a very early stage, and a single time point measure wouldn't find significant biomarker levels, if clinicians do accumulative measures, they should be able to catch it. Then, they can tell if they are increasing or measure their rate of change, also called the biomarker velocity. For more, find him on twitter through @HellerLab and see the lab web site at https://www.mskcc.org/research/ski/labs/daniel-heller #therapeutics #biotech #CancerDetection ... https://www.youtube.com/watch?v=-40BBW6ekK8

Cancer might be a third category of cell type, thinks clinician Doru Paul. He discusses the continuous interaction and communication between tumor cells versus normal cells that make cancer a disease of the macro environment. Listen and learn 1. Why cancer is a multi-level disease, with influences beyond the cancer and genetics connection, 2. What is known and unknown about the first cells that make cancer, 3. How the metastatic process is primarily an epigenetic process and why that's significant, and 4. What makes the role of cell metabolism and energy fundamental in understanding cancer. ... https://www.youtube.com/watch?v=OeLicCW0X64