Videos mentioned: PFS: https://youtu.be/tx8c3BvfuWw https://youtu.be/iDeDcBg4esk https://youtu.be/ykk3UVyeCiA https://youtu.be/PVLJMwUFDvI https://youtu.be/YM4DJbK9HQY Minoxidil and tretinoin: https://youtu.be/hj4WU3hmc9w Oral minoxidil: https://youtu.be/CAoEP3pO7Po https://youtu.be/2zxNnUB5PPQ https://youtu.be/t-QgZ5dmkYk Sources: 1. New USPSTF Recommendation on Aspirin in CVD: No For Primary Prevention, Yes For Secondary Prevention - American College of Cardiology. Accessed January 2, 2023. https://www.acc.org/latest-in-cardiology/articles/2022/04/27/20/41/new-uspstf-recommendation-on-aspirin-in-cvd 2. Bombardier C, Laine L, Reicin A, et al. Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. VIGOR Study Group. N Engl J Med. 2000;343(21):1520-1528, 2 p following 1528. doi:10.1056/NEJM200011233432103 3. Karha J, Topol EJ. The sad story of Vioxx, and what we should learn from it. Cleveland Clinic Journal of Medicine. 2004;71(12):933-934. doi:10.3949/ccjm.71.12.933 4. Bresalier RS, Sandler RS, Quan H, et al. Cardiovascular Events Associated with Rofecoxib in a Colorectal Adenoma Chemoprevention Trial. New England Journal of Medicine. 2005;352(11):1092-1102. doi:10.1056/NEJMoa050493 5. Curfman GD, Morrissey S, Drazen JM. Expression of Concern: Bombardier et al., “Comparison of Upper Gastrointestinal Toxicity of Rofecoxib and Naproxen in Patients with Rheumatoid Arthritis,” N Engl J Med 2000;343:1520-8. New England Journal of Medicine. 2005;353(26):2813-2814. doi:10.1056/NEJMe058314 6. Berenson A. Scientists Again Defend Study on Vioxx. The New York Times. https://www.nytimes.com/2006/02/23/business/scientists-again-defend-study-on-vioxx.html. Published February 23, 2006. Accessed December 31, 2022. 7. Caldwell B, Aldington S, Weatherall M, Shirtcliffe P, Beasley R. Risk of cardiovascular events and celecoxib: a systematic review and meta-analysis. J R Soc Med. 2006;99(3):132-140. Accessed January 2, 2023. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1383759/ 8. Kearney PM, Baigent C, Godwin J, Halls H, Emberson JR, Patrono C. Do selective cyclo-oxygenase-2 inhibitors and traditional non-steroidal anti-inflammatory drugs increase the risk of atherothrombosis? Meta-analysis of randomised trials. BMJ. 2006;332(7553):1302-1308. doi:10.1136/bmj.332.7553.1302 9. Culp DR, Berry I. Merck and the Vioxx Debacle: Deadly Loyalty. 2007;22. 10. Warren TY, Barry V, Hooker SP, Sui X, Church TS, Blair SN. Sedentary Behaviors Increase Risk of Cardiovascular Disease Mortality in Men. Med Sci Sports Exerc. 2010;42(5):879-885. doi:10.1249/MSS.0b013e3181c3aa7e 11. Bartkus ME. The Cost to Society of Pharmaceutical Mass Tort Litigation. SSRN Journal. Published online 2019. doi:10.2139/ssrn.3402725 ... https://www.youtube.com/watch?v=5iR4mQaXyYQ

Hey, chooms, just a word of caution. If you post a link in a comment, there is a good chance that YouTube will automatically delete it, because it thinks comments with links are spam. I am not deleting your comments. If you want to post a research study, just post the title of the study, and I can google it to get the link. Videos mentioned: Wnt pathway: https://youtu.be/RUEQ0TtjlDA Broccoli theory: https://youtu.be/uJpeHKKGd74 Sonic Hedgehog Pathway: https://youtu.be/Uk8LUxcDQZg Sources: Chew, Elaine G. Y., Joanna H. J. Tan, Adiam W. Bahta, Bryan S. -Y. Ho, Xingliang Liu, Tze Chiun Lim, Yee Yen Sia, et al. 2016. “Differential Expression between Human Dermal Papilla Cells from Balding and Non-Balding Scalps Reveals New Candidate Genes for Androgenetic Alopecia.” Journal of Investigative Dermatology 136 (8): 1559–67. https://doi.org/10.1016/j.jid.2016.03.032. Harshuk-Shabso, Sarina, Hila Dressler, Christof Niehrs, Emil Aamar, and David Enshell-Seijffers. 2020. “Fgf and Wnt Signaling Interaction in the Mesenchymal Niche Regulates the Murine Hair Cycle Clock.” Nature Communications 11 (1): 5114. https://doi.org/10.1038/s41467-020-18643-x. Heilmann-Heimbach, Stefanie, Lara M. Hochfeld, Ralf Paus, and Markus M. Nöthen. 2016. “Hunting the Genes in Male-Pattern Alopecia: How Important Are They, How Close Are We and What Will They Tell Us?” Experimental Dermatology 25 (4): 251–57. https://doi.org/10.1111/exd.12965. Osborn, Dorothy. 1916. “INHERITANCE OF BALDNESS.” Journal of Heredity 7 (8): 347–55. https://doi.org/10.1093/oxfordjournals.jhered.a110746. ProposalInside7538. 2022. “TWIST-1 and the Cure: Is It Really That Easy?” Reddit Post. R/Tressless. www.reddit.com/r/tressless/comments/w436w5/twist1_and_the_cure_is_it_really_that_easy/. Shiota, M., A. Yokomizo, Y. Tada, J. Inokuchi, E. Kashiwagi, D. Masubuchi, M. Eto, T. Uchiumi, and S. Naito. 2010. “Castration Resistance of Prostate Cancer Cells Caused by Castration-Induced Oxidative Stress through Twist1 and Androgen Receptor Overexpression.” Oncogene 29 (2): 237–50. https://doi.org/10.1038/onc.2009.322. Xu, Yan, Yixiang Xu, Lan Liao, Niya Zhou, Sarah M. Theissen, Xin-Hua Liao, Hoang Nguyen, et al. 2013. “Inducible Knockout of Twist1 in Young and Adult Mice Prolongs Hair Growth Cycle and Has Mild Effects on General Health, Supporting Twist1 as a Preferential Cancer Target.” The American Journal of Pathology 183 (4): 1281–92. https://doi.org/10.1016/j.ajpath.2013.06.021. Yu, Nanlan, Tianxing Hu, Haichao Yang, Lian Zhang, Qin Song, Fei Xiang, Xichuan Yang, and Yuhong Li. 2020. “Twist1 Contributes to the Maintenance of Some Biological Properties of Dermal Papilla Cells in Vitro by Forming a Complex With Tcf4 and β-Catenin.” Frontiers in Cell and Developmental Biology 8. https://www.frontiersin.org/articles/10.3389/fcell.2020.00824. ... https://www.youtube.com/watch?v=teCnoG2o3ZE