A lawsuit is brought against Chase and House for the death of a mother (Allison Smith) who comes in with stomach pain. A disciplinary committee convenes to determine whether either of them is at fault.

When a man (Eddie Mills) cannot breathe during sexual role playing with his wife, House questions the motives behind their marriage; Wilson's presence in his house begins to take a toll on him.

An ad by a 527 group attacking Santos for his pro-choice stand has both campaigns up in arms, trying to avoid the campaign going negative or diving into the abortion issue — a touchy subject for both candidates: Vinick because his pro-choice position risks alienating pro-life conservatives, Santos because his risks alienating pro-choice liberals, including a major pro-choice interest group who are considering endorsing Vinick. Back at the White House, Will struggles with dealing with the press as the new Communications Director, settling into Toby's old office. Josh struggles with Lou Thornton's decision to bring Donna into the campaign as a spokesperson. In the final moments, as both candidates wait backstage at the Alfred E. Smith Memorial Foundation Dinner, Santos and Vinick agree to an unexpected deal: a live debate the following Sunday.

On the day before Thanksgiving, the President is talking turkey to whoever will listen (and everyone must). Meanwhile, C.J. deals with two Native Americans who have encamped in the lobby. Toby annoys the President when he finds out polls involving the First Family increase his popularity. Sam is dismayed by a new formula for poverty and Josh goes diplomatic on a case involving a Georgia teen who killed his teacher and fled to Italy.