Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional. ... https://www.youtube.com/watch?v=T56cBGUHbO4
My opinion is that you keep the correct levels of vitamin D in your body. Now a days, due to staying indoors, it is possible that you will develop the deficiency of vitamin D. Get this checked by your doctor and use the correct dose to stay healthy.
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Here are my notes:
Daily 10 microgram or 400 IU/Day
Lippincott’s Biochemistry Review 4th Edition. Page 388
Daily 5 mg of cholecalciferol or 200 IU of Vitamin D.
However, 800 IU/Day is shown to reduce the incidence of osteoporotic fractures.
800 IU/Day recommended by the Institute of Medicine to maintain bone health.
Frank deficiency is when the levels of 25-hydroxycholecalciferol (25OHD) is less than 20 ng/mL (50 mmol/L)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305614/
No consensus that the oral vitamin D supplements are helpful
Ergocalciferol from plants is called Vitamin D2
Cholecalciferol from the animal tissue is called Vitamin D3
7 deidro-cholesterol to (UV light) to cholecalciferol (D3) to 25 hydroxylase in liver to 25 OH D to -hydroxycholecalciferol 1-hydroxylase in kidney to 1,25 DiOH D3
Vitamin D Receptors are abbreviated to VDR in the notes. These are cytosolic receptors.
https://www.newscientist.com/article/2121424-vitamin-d-supplements-may-prevent-millions-of-winter-infections/
Deficiency of vitamin D makes people more susceptible to respiratory tract infections.
Vitamin D supplement can reduce these infections by 12%
Keep in mind, this is for those who are deficient in this vitamin. If you are not deficient, then it will not make a difference. Because, you are already good.
Evidence is not sufficient to say that vitamin D helps prevent respiratory infections.
2018 Study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305614/
People with autoimmune diseases commonly have hypovitaminosis D
What are cathelicidins?
https://www.sciencedirect.com/topics/neuroscience/cathelicidin
What are beta defensins?
https://en.m.wikipedia.org/wiki/Beta_defensin
2011 Study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166406/
Activation of TLR and PAMPs on macrophages increases the production of 1, alpha hydroxylase and the VDR. This in turn causes more production of cathelicidine and beta defensins 4.
Vitamin D also affects monocytes to reduce production of IL1, IL6, IL8, IL12, and TNF. Regulating the immune response.
Vitamin D acts on the dendritic cells to inhibit/reduce their differentiation and maturation. It reduces their MHCII expression, co-stimulatory molecules like CD40, CD80, CD86, decreased production of IL-12 etc.
2013 Study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756814/
Vitamin D improves immune system by helping produce cathelicidine and by helping modulate inflamm
...
https://www.youtube.com/watch?v=wJyT1YSwe-8
Boston University Creates A Chimeric Variant Omi-S (Preprint Study)
Did they really perform gain of function to create a more lethal variant? Let's review their preprint paper.
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
URL list from Tuesday, Oct. 18 2022
29782899
https://www.biorxiv.org/content/10.1101/2022.10.13.512134v1.full.pdf
Researchers’ tests of lab-made version of Covid virus draw scrutiny
https://www.statnews.com/2022/10/17/boston-university-researchers-testing-of-lab-made-version-of-covid-virus-draws-government-scrutiny/
Outrage as Boston University CREATES Covid strain that has an 80% kill rate | Daily Mail Online
https://www.dailymail.co.uk/health/article-11323677/Outrage-Boston-University-CREATES-Covid-strain-80-kill-rate.html
NEIDL Researchers Refute UK Article about COVID Strain | The Brink | Boston University
https://www.bu.edu/articles/2022/neidl-researchers-refute-uk-article-about-covid-strain/
Mohsan Saeed | Profiles RNS
https://profiles.bu.edu/Mohsan.Saeed
...
https://www.youtube.com/watch?v=q8RH7z-yGVM
Unexpected vaginal bleeding and COVID-19 vaccination in nonmenstruating women
Researchers from Department of Method Development and Analytics, Norwegian Institute of Public Health, Oslo, Norway demonstrated the evidence of increased risk of unexpected vaginal bleeding in non-menstruating women after the mRNA COVID vaccines. Let's review their evidence.
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URL list from Friday, Sep. 29 2023
DrBeen: Medical Education Online
https://www.drbeen.com/
Unexpected vaginal bleeding and COVID-19 vaccination in nonmenstruating women | Science Advances
https://www.science.org/doi/10.1126/sciadv.adg1391
New Study Reviewed Vaginal Bleeding In Non-menstruating Women After Covid-19 Vaccination
https://www.forbes.com/sites/ninashapiro/2023/09/29/new-study-reviewed-vaginal-bleeding-in-non-menstruating-women-after-covid-19-vaccination/?sh=561cdeb16f12
Women say COVID vaccines affected their periods. A new study adds to mounting evidence.
https://www.yahoo.com/lifestyle/covid-vaccines-period-changes-011241035.html?guccounter=1
Unexpected vaginal bleeding and COVID-19 vaccination in nonmenstruating women
file:///C:/Users/s_mob/Downloads/sciadv.adg1391.pdf
Defining Menopausal Status in Epidemiologic Studies: A Comparison of Multiple Approaches and their Effects on Breast Cancer Rates - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922404/#:~:text=In%20a%20fourth%20%60combined%20simplistic,premenopausal%20(age%20%3C55%20and%20menstrual
Hormonal IUDs
https://www.plannedparenthood.org/learn/birth-control/iud/hormonal-iuds#:~:text=IUD%20stands%20for%20Intrauterine%20Device,your%20body%20over%20several%20years.
Endometrial Decidualization: The Primary Driver of Pregnancy Health - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312091/#:~:text=Decidualization%20refers%20to%20the%20functional,cells%20(ESCs)%20into%20DSCs.
Decidua - Wikipedia
https://en.wikipedia.org/wiki/Decidua
Frontiers | Endometrial and Menstrual Blood Mesenchymal Stem/Stromal Cells: Biological Properties and Clinical Application
https://www.frontiersin.org/articles/10.3389/fcell.2020.00497/full#:~:text=Endometrial%20stromal%20fibroblasts%20naturally%20differentiate,establishment%20and%20continuation%20of%20pregnancy.
...
https://www.youtube.com/watch?v=yHeLiO9Ib5g
Study - Spike Proteins in Plasma of Vaccinated (Nothing After The Second Dose)
A small study on healthcare workers demonstrated the production and detection of S1 part of the spike protein and Spike proteins in the plasma of the individuals vaccinated with Moderna vaccine. Let’s review the study.
Study link
https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciab465/6279075
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...
https://www.youtube.com/watch?v=6P8FZwQgQu8
Random COVID Questions with Dr. Been (#80)
Let’s discuss your COVID questions.
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...
https://www.youtube.com/watch?v=Ef0wGQ669S0
What Are Cancers? Cancer Immunology (Part 2) with Prof. Dr. William Murphy
Dr. William J. Murphy is a scientist with extensive experience with immune and the cancer system interactions. Dr. Murphy has graciously offered to help us understand cancer immunology.
Today we will focus more on the CAR-T therapy.
Brief bio of Dr. Murphy:
My research for the past 30 years has centered on translational studies involving modeling cancer-immune system interactions starting with my earlier studies on NK cells and HSCT in mouse models and later at the National Cancer Institute on their role in cancer immunotherapy which then expanded to issues in immunotherapy in general.
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
References with some previous talks
COVID Research - A Talk With Dr. William J. Murphy - YouTube
https://www.youtube.com/watch?v=UdmaZX3ftfY
Dr. William J. Murphy, Ph.D. for UC Davis Health
https://health.ucdavis.edu/team/search/1226/william-murphy---cancer---dermatology---hematology-oncology---pathology---dermatopathology-sacramento
A Possible Role for Anti-idiotype Antibodies in SARS-CoV-2 Infection and Vaccination | NEJM
https://www.nejm.org/doi/full/10.1056/NEJMcibr2113694
Autoimmune Disease after Infection or Vaccine in Some (Article Review of Anti-idiotype Antibodies) - YouTube
https://www.youtube.com/watch?v=kE9UUX7NV5Q
...
https://www.youtube.com/watch?v=YgrY5avVA64
Cystic fibrosis is the most common hereditary disease which causes death in the United States in children and young adults.
Cystic fibrosis is due to a mutation in a gene (phenylalanine) on chromosome 7.
The cystic fibrosis gene encodes a protein known as the cystic fibrosis transmembrane regulator (CFTR).
The abnormal CFTR protein in patients with cystic fibrosis leads to the disruption of chloride channels on the cells.
Dr. Mobeen Syed discusses the mechanism of production of thick secretion in cystic fibrosis patients.
Usually, in the production of secretions, there is a secretion of chloride ions and reabsorption of sodium ions along with water.
On the other hand, when the CFTR complex is abnormal, there is the trapping of chloride ions inside the secretory cells due to the disruption of chloride channels.
Sodium channels become hyperactive, causing increased reabsorption of sodium along with water.
The secretions become devoid of ions.
The fluid in the secretion becomes isotonic. There is the formation of a thin layer of thick-dehydrated solution.
This mechanism occurs in all the secretions of the body, including respiratory, pancreatic, liver, and gallbladder secretions.
The thick secretions cause obstructions in the glands and ducts of affected organs. It leads to dilatation of the secretory glands. It also damages the exocrine tissue.
The following topics have discussed in the video:
* Cystic fibrosis
* Normal production of secretions
* Abnormality in CFTR complex
* Abnormal production of secretions
...
https://www.youtube.com/watch?v=59jzCtY5V5E
Many Legal COVID Thoughts by Paul Bork
As promised Paul Bork will discuss the COVID related legal landscape. We will continue this series of legal landscape review if you liked it.
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
...
https://www.youtube.com/watch?v=nqd-B3plC0c
Fascinating Questions with Dr. Been (#184)
Let's have fun and talk :-)
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
...
https://www.youtube.com/watch?v=TRh9MKaMYLg