This is a detailed account of my lost in geron, in September of 2018. This was a very pivotal learning experience from me and influenced my trading styles to this day and learning also to properly manage my risks and have a real strategy in place. Geron Corporation, located in Menlo Park, Calif., announced that Janssen Pharmaceutical Inc., a Johnson & Johnson company, has terminated their 2014 Collaboration and License Agreement. The two companies had teamed up to develop and commercialize imetelstat, a first-in-class telomerase inhibitor, for myelofibrosis and myelodysplastic syndromes. The effective date of termination, under the collaboration deal, is September 28, 2018. At that time, the rights licensed to the imetelstat program, which includes any intellectual property rights created via the collaboration, return to Geron. Janssen will have no further obligations to fund any of the ongoing clinical trials. The transition will take place over approximately 12 months with operational assistance from Janssen. Janssen will supply imetelstat to Geron for up to two years. Two clinical trials of imtelstat, IMbark for myelofibrosis and IMerge for myelodysplastic syndromes, will continue. “We believe the clinical results from IMbark provide valuable insights into the potential future development of imetelstat for an underserved relapsed and refractory myelofibrosis patient population. We also believe the combined data of 38 patients from the initial and expansion cohorts for the target patient population from the Phase II portion of IMerge support further development of imetelstat, and we are therefore prioritizing the initiation of the Phase III portion of IMerge.” IMerge is a two-part clinical trial testing the drug in transfusion-dependent patients with low or immediate-1 risk myelodysplastic syndromes who have relapsed after or are refractory to previous treatment with an erythropoiesis-stimulating agent (ESA). Part one was planned as a Phase II, open-label, single-arm trial to evaluate efficacy and safety. Part two is planned as a Phase III double-blind, randomized, placebo-controlled study in about 170 patients. The primary endpoint is the rate of red blood cell transfusion independent (RBC-TI rate) lasting at least eight weeks. In part 1 of Phase II, 32 patients were enrolled, with 13 patients who had not had previous treatment with a hypomethylating agent (HMA) or lenalidomide and didn’t have a del(5q) chromosomal abnormality, which is to say, did not have a portion of the q arm of their chromosome 5 deleted. IMbark was a Phase II trial to study starting dose levels of the drug in about 200 patients with intermediate-2 or high-risk myelofibrosis (MF) who had relapsed after or are refractory to previous treatment with a JAK inhibitor ... https://www.youtube.com/watch?v=c-lp8JVOv1c

Here Is my follow up video to my change of lifestyle habits and what happened when I stopped drinking alcohol. Excessive drinking does a lot of long-term damage to the body. According to the National Institute on Alcohol Abuse and Alcoholism, abusing alcohol can impair the immune system, harm our organs and increase cancer risk. The most obvious immediate side effects of drinking are related to the harm it causes to the brain. You feel dizzy, confused and disoriented right after drinking a lot of alcohol. The next day, you feel groggy and may have a headache. Other common physical side effects of alcohol include nausea, vomiting and low body temperature. These effects are symptoms of the internal damage that alcohol causes. Vital organs and other internal parts of the body can recover from infrequent, moderate drinking. But the regular binge drinking and heavy drinking that often accompany alcohol addiction can cause long-term damage that lowers your quality of life. Drinking this way increases your chances of developing numerous alcohol-related diseases. Fortunately, the body can usually bounce back if you quit drinking. Recovery from liver damage may even be possible. You may not realize that alcohol is hurting your everyday health until you quit drinking and start to feel better. ... https://www.youtube.com/watch?v=ZrKP3j2N8t0