### Keywords ###
#Atomicleveldescriptions #proteinsmallmolecule #largeconformational #conformationalchange #moleculebinding #bindingprocesses #Ablkinase #RTCLTV #shorts
### Article Attribution ###
Title: Structural mechanism of a drug-binding process involving a large conformational change of the protein target
Authors: Pelin Ayaz, Agatha Lyczek, YiTing Paung, Victoria R. Mingione, Roxana E. Iacob, Parker W. de Waal, John R. Engen, Markus A. Seeliger, Yibing Shan ,and David E. Shaw
Publisher: Nature Portfolio
DOI: 10.1038/s41467-023-36956-5
DOAJ URL: https://doaj.org/article/e9aae3578aa946d8ba5c8a7f929b7cf9
Source URL: https://doi.org/10.1038/s41467-023-36956-5
### Image Attribution ###
We used stable diffusion to programmatically generate the background images.
Viewer discretion is advised.
### Channels ###
YouTube Channel: https://www.youtube.com/@stemrtcltv
Odysee Channel: https://odysee.com/@stem_rtcl_tv
### Video Timestamps ###
0:00:00 - Summary
0:00:17 - Title
0:00:23 - End
### Keywords ###
#amyloidcrystals #amyloidfibrils #amyloidpolymorphism #nanomechanicalproperties #secondarystructure #RTCLTV #shorts
### Article Details ###
Title: Evolution of Conformation, Nanomechanics, and Infrared Nanospectroscopy of Single Amyloid Fibrils Converting into Microcrystals
Authors: Jozef Adamcik, Francesco Simone Ruggeri, Joshua T. Berryman, Afang Zhang, Tuomas P. J. Knowles ,and Raffaele Mezzenga
Publisher: Wiley
DOI: 10.1002/advs.202002182
DOAJ URL: https://doaj.org/article/d08c5ef0afe6488bb81552dd1465ae27
Source URL: https://doi.org/10.1002/advs.202002182
### Image Attribution ###
We used stable diffusion to programmatically generate the background images. Viewer discretion is advised.
### Channels ###
YouTube Channel: https://www.youtube.com/@stemrtcltv
Odysee Channel: https://odysee.com/@stem_rtcl_tv
### Video Timestamps ###
0:00:00 - Summary
0:00:37 - Title
0:00:55 - Outro
0:01:03 - End