Two children wake up in the middle of the night to find their father is missing, and all the windows and doors in their home have vanished.

After an odd new medical student arrives on campus, a dedicated local and his girlfriend become involved in bizarre experiments centering around the re-animation of dead tissue.

When a teenage girl is possessed by a mysterious entity, her mother seeks the help of two priests to save her daughter.

Alex Browning is among a group of high school students readying themselves for a trip to Europe. When he suddenly has a premonition their airplane will crash, he screams to warn the others but instead he is thrown off of the plane along others, but the plane actually crashes after they get off. Weeks later one of the survivors mysteriously dies, and Alex realizes that things just got more complex.