After an odd new medical student arrives on campus, a dedicated local and his girlfriend become involved in bizarre experiments centering around the re-animation of dead tissue.
A controversial true crime writer finds a box of super 8 home movies in his new home, revealing that the murder case he is currently researching could be the work of an unknown serial killer whose legacy dates back to the 1960s.
Alex Browning is among a group of high school students readying themselves for a trip to Europe. When he suddenly has a premonition their airplane will crash, he screams to warn the others but instead he is thrown off of the plane along others, but the plane actually crashes after they get off. Weeks later one of the survivors mysteriously dies, and Alex realizes that things just got more complex.
Five friends head out to rural Texas to visit the grave of a grandfather. On the way they stumble across what appears to be a deserted house, only to discover something sinister within. Something armed with a chainsaw.